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Special Issue  |   November 2018
Sleep Disorders are a Prevalent and Serious Comorbidity in Dry Eye
Author Affiliations & Notes
  • Masahiko Ayaki
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Otake Clinic Moon View Eye Center, Yamato, Japan
  • Kazuo Tsubota
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
  • Motoko Kawashima
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
  • Taishiro Kishimoto
    Department of Psychiatry, Keio University School of Medicine, Tokyo, Japan
  • Masaru Mimura
    Department of Psychiatry, Keio University School of Medicine, Tokyo, Japan
  • Kazuno Negishi
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
  • Correspondence: Masahiko Ayaki, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjyukuku, Tokyo, 1608582, Japan;
  • Kazuno Negishi, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjyukuku, Tokyo, 1608582, Japan;
Investigative Ophthalmology & Visual Science November 2018, Vol.59, DES143-DES150. doi:10.1167/iovs.17-23467
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      Masahiko Ayaki, Kazuo Tsubota, Motoko Kawashima, Taishiro Kishimoto, Masaru Mimura, Kazuno Negishi; Sleep Disorders are a Prevalent and Serious Comorbidity in Dry Eye. Invest. Ophthalmol. Vis. Sci. 2018;59(14):DES143-DES150. doi: 10.1167/iovs.17-23467.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: Sleep is an essential life habit and closely associated with lifespan, diabetes, hypertension, and mental health. Sleep disorders are a prominent, but overlooked problem in patients with dry eye disease (DED), characterized by a poor sleep index, short sleep duration, long sleep latency, and poor subjective sleep. DED and sleep disorders are more prevalent in women than men. Moreover, sleep quality in DED is worse than in other eye diseases, including glaucoma, retinal diseases, cataract, and allergic and chronic conjunctivitis.

Methods: We reviewed the literature for studies investigating sleep and health, eyes and sleep, and DED and sleep, in terms of systemic and eye health, especially in women.

Results: Two studies reported that approximately half of patients with DED suffer from poor sleep. The severity of mood disorders, including anxiety and depression, is correlated strongly with sleep disorders in DED, and the symptoms and signs of DED, especially pain, also are correlated with sleep quality. Sleep disorders are documented in primary Sjögren's syndrome and an association with sleep apnea and depression is suggested. Primary Sjögren's syndrome includes arthritis and other rheumatic disease causing pain and fatigue; however, how sicca contributes to sleep disorders is not known.

Conclusions: Possible explanations for sleep disorders in DED may be depression, pain, and eye exposure at night. Reciprocal effects may be expected and consultation-liaison psychiatry is recommended for the management of sleep disorders in DED. Topical medication and lid heating also may be advantageous for sleep quality in DED.

A sleep disorder is a serious health problem and eye diseases may be linked to sleep in many aspects.1 There is an increased interest in the psychiatric profile of patients with dry eye disease (DED),2,3 including depression and sleep disorders, since a neurologic and psychiatric pathophysiology may underlie DED. Since DED4,5 and sleep disorders6,7 are more prevalent in women than men, we reviewed sleep and health, eyes and sleep, and DED and sleep in terms of the systemic and eye health, especially of women. 
Recent Progress in Japan and Around the World
Sleep disorders are a new aspect in the care of DED. This concept was first introduced in 2015, and to date, few reports have been published in this field. Epidemiologic studies, including cohort and case-control studies, have been published in the United States, Korea, and Japan. A detailed psychiatric and neurologic approach looking at the mental health of patients with DED may further contribute to sleep quality in DED. 
Sleep is a Critical Habit for Life
Sleep is an essential event for life, and sleep disorders are closely associated with mortality,810 motor accidents,11 injuries, and mistakes.12,13 Several diseases have a significant association with sleep disorders and sleep duration, including depression,14,15 diabetes,16 obesity,17,18 hypertension,19 and cardiovascular events.20,21 Sleep disorders may be induced by systemic or brain disorders, medication, depression or other psychiatric disorders, aging, environmental problems, or inadequate lighting. Transmeridian air travel and social activity also may cause sleep and circadian rhythm disorders.22 
The gold standard for evaluating sleep quality is an electroencephalogram (polysomnography). Other objective methods used in chronobiologic and sleep studies include actigraphy,23,24 which uses a micromotion logger to record the sleep/wake cycle and is compatible with an electroencephalogram, and measurement of melatonin levels in the blood, saliva, and urine.25 Subjective sleep quality can be measured with a sleep diary and questionnaire. The most popular and validated self-report questionnaire is the Pittsburg Sleep Quality Index (PSQI) and major parameters are sleep duration, sleep latency, sleep difficulty, subjective sleep, and sleep efficacy.26 
Menopausal Women Suffer From Dry Eye and Sleep Disorders
DED develops predominantly in menopausal women and they are at risk for a variety of health problems, including sleep and mood disorders,27 and sleep apnea syndrome.28 Circadian rhythm disorders complicated with sleep disorders increase the risk of breast cancer by as much as 1.5-fold.29 Vasomotor symptoms, major symptom during menopause, may lead to a sleep disorder,30 but sleep disorders in menopausal women are associated more closely with depression than vasomotor symptoms.31 Sleep latency and anxiety are correlated with depression32 and sleep medicine is effective.33 Hormone replacement therapy (HRT) with estrogen is known to be effective for menopausal symptoms, including sleep.3436 One study37 suggested that HRT may be effective for DED; however, this finding is controversial since other strictly controlled studies3840 have suggested that women who use HRT, particularly estrogen alone, are at increased risk of DED. Ophthalmologists caring for women who are taking or considering HRT should be aware of this potential adverse effect. 
Close Association between DED and Sleep
The Pivotal Role of Eyes in Sleep
Sleep is regulated by the circadian clock located in the suprachiasmatic nucleus.41 Eyes have a pivotal role in sleep, since intrinsically photosensitive retinal ganglion cells and melanopsin are major players for photoreception to reset the circadian clock.42,43 The function of intrinsically photosensitive retinal ganglion cells is mostly a nonvisual response of photoreception of short wavelength light. Glaucoma44 and cataracts45 negatively affect retinal photoreception and intraocular transmittance of light, respectively, and have been investigated as a potential cause of sleep disorders in the elderly. Glaucoma may share similar sleep problems with DED, as discussed later. 
Sleep Disorders are Prevalent and Severe in DED
A survey of 1000 visitors to general eye clinics in Japan1 revealed that 18.0% had DED and PSQI results demonstrated that 42.1% of the patients with DED were poor sleepers (PSQI global score ≥ 6; Table). This was the highest percentage for all diagnostic groups, including glaucoma (34.9%), retinal disease (35.0%), and cataract (39.6%). The depression and anxiety index (Hospital Anxiety and Depression Scale [HADS])46 also was poorest in the DED group (HADS score ≥ 10 in 43.5%), compared to other diagnostic groups, such as glaucoma (38.8%), retinal disease (43.2%), and cataract (36.9%). In addition, the DED group had the poorest subjective sleep, sleep duration, anxiety, and depression subscores, suggesting poor sleep quality in DED might be associated with mental status. 
Studies Evaluating Dry Eye and Sleep
Studies Evaluating Dry Eye and Sleep
Kawashima et al.47 reported the results of a survey of 383 office workers routinely involved in video display terminal tasks and the prevalence of DED was 65.0% in this cohort. The prevalence of sleep disorders was 45.0% and the mean PSQI was 5.4 ± 2.2 in this DED group, according to the same criteria as Ayaki et al.1 (PSQI > 5.5), whereas the values for the non-DED group were 33.6% and 4.6 ± 2.3, respectively. The presence of DED, the Schirmer value, and DED symptom score were significantly correlated with PSQI. It is notable that the prevalence of sleep disorders and the PSQI in the DED group were similar in these two studies despite the mean age of the DED groups differing by 19 years (61.4 vs. 42.4 years), suggesting that video display terminal work may negatively affect sleep. Based on the results of these two studies, nearly half the patients with DED suffer from poor sleep and it may be associated with DED symptoms and mental status. 
In a study of women aged 30–69 years, with and without DED,48 the DED group exhibited a significantly poorer PSQI score than the non-DED group, especially in subjects 56 to 69 years old (4.92 ± 2.71, non-DED; 6.08 ± 2.92, DED), suggesting subjective sleep quality in the older group may be exacerbated by DED. On the other hand, the younger group (30–45 years) with DED showed a poorer mood index (HADS score, 13.18 ± 3.95) compared to the non-DED group (9.79 ± 5.82), suggesting that the younger group may be the most distressed of the three age groups of women. Across all age groups, the PSQI score was strongly correlated with the HADS score. These results demonstrated that DED has a considerable impact on sleep and mood in women. 
Lee et al.49 reported survey results of sleep duration in 15,878 Korean participants divided into five groups according to habitual sleep duration (≤4, 5, 6–8, 9, and ≥10 hours), and demonstrated that the prevalence of DED was correlated with sleep duration, with an odds ratio (OR) for DED prevalence, after adjusting for age, sex, and sociodemographic factors (smoking habit, alcohol consumption, and level of exercise), of 1.30 for a short sleep (≤4 hours), 1.2 for 5 hours, 0.89 for 9 hours, and 1.0 for ≥ 10 hours, compared to optimal sleep (6–8 hours). They discussed the significant association of sleep deprivation with DED risk, in relation to increased inflammation by tear hyperosmolarity, androgen levels, the parasympathetic nervous system, and blinking. 
Ong et al.50 assessed symptom progression in DED and determined ocular and nonocular risk factors associated with severe symptoms at 1 year in a longitudinal study of 120 veterans (mean age, 64 years). Nonocular risk factors included sleep disturbances (e.g., sleep apnea and insomnia), mental health status (e.g., posttraumatic stress disorder and depression), nonocular pain, and medications (e.g., anxiolytics and analgesics). Multivariable analysis revealed the most significant nonocular risk factors were sleep apnea (OR, 3.80), the Dry Eye Questionnaire 5 score (OR, 1.15), and the posttraumatic stress disorder score (OR, 1.04). 
Galor et al.51 investigated the association between DED and insomnia symptom severity in 187 patients (mean age, 63 years) and the DED group with high pain experienced more severe insomnia compared to the DED low pain group. They evaluated the pain of DED using numeric rating scales for pain, spontaneous burning pain, and sensitivity to wind and light. Black race, depression severity, and DED symptom severity were significantly associated with clinical insomnia. This investigation suggests that ocular pain may lead to sleep disorders in DED. Pain is known to be a serious issue for sleep quality52 and it may explain why sleep disorders are seen in primary Sjögren's syndrome (pSS), as described later. 
Sex Difference in Sleep Disorders in DED
Sleep disorders in women with DED aged 30 to 69 years are characterized by a poor PSQI global score (4.92 ± 2.71 for non-DED vs. 6.08 ± 2.92 for DED), poor subjective sleep score (1.10 ± 0.58 vs. 1.35 ± 0.77, respectively), longer sleep latency (16.0 ± 15.0 vs. 22.2 ± 22.8 minutes, respectively), and a late bedtime (23:30 ± 1:08 vs. 23:56 ± 1:07 hours, respectively).48 The HADS score also is worse for women with (11.36 ± 6.27) than without (9.93 ± 5.40) DED. Using the same cohort as above, the PSQI and HADS scores were calculated for 114 men without and 38 with DED, aged 30 to 69 years (unpublished data). The men with DED showed significantly poorer results for the PSQI global score and subjective sleep score than men without DED. In addition, men with DED exhibited a poorer daytime dysfunction score and shorter sleep duration than men without DED. Using the PSQI global score, the severity of sleep disorders between men and women with DED is similar; however, the HADS score for men is not different between the DED and non-DED groups, suggesting depression and anxiety may have a stronger impact on the sleep of women with DED than on men with DED. 
More Severe Sleep Disorders Occur With DED than Other Irritating Eye Diseases
According to a survey of patients with DED, chronic conjunctivitis, and allergic conjunctivitis, those with DED showed the poorest PSQI and HADS scores53 (6.4 ± 3.3 and 11.1 ± 6.6 for severe DED, 5.5 ± 3.1 and 9.8 ± 5.7 for mild DED, 5.5 ± 3.2 and 9.5 ± 5.6 for chronic conjunctivitis, and 5.0 ± 2.8 and 8.9 ± 6.0 for allergic conjunctivitis, respectively). Sleep duration and sleep efficacy also were poorest in the severe DED group. The investigators speculated that patients with DED may be distressed by sensory discomfort, optical disturbance, or by psychologic distress from the disease itself. These factors affect patients and may lead to depression and sleep disorders. Patients with DED suffer from irritation and dryness and these symptoms may continue for life and can worsen at any time, which is the nature of the difference of DED from chronic conjunctivitis and allergic conjunctivitis. 
Eyes are Disturbed at Night With DED
The results of closed-eye studies and elevated tear matrix metaprotease-9 in DED suggest that patients with DED may have more inflammatory processes than controls during sleep.54,55 Patients with DED have a high prevalence of obstructive sleep apnea,5659 and its therapy, continuous positive airway pressure, may worsen DED.60 Air conditioning and sleep position61,62 also may worsen DED. Asplund63 reported that nocturia is more prevalent in people with ocular and oral dryness than in those without, according to the survey results of 6103 elderly participants. Sleep deprivation reduces tear secretion and impairs the tear film.64 Patients with DED have uncomfortable eyes in the morning and they are unhappy, as indicated by a web survey (Kokune-Takahashi A, et al. IOVS 2017;58:ARVO Asia Poster 159). 
In 1994, Kurihashi65 described a unique therapy for DED and sleep disorders of wearing a moisture aid consisting of a wet gauze eye mask during sleep; this has become an established treatment for chronic blepharitis.6668 
DED has a Considerable Psychiatric Profile
Several reports and reviews describe a close association between DED and depression, anxiety, stress, posttraumatic stress disorder, and sleep disorders. On the other hand, sleep deprivation and medications for psychiatric disorders may partly suppress tear secretion because lacrimal secretion is under neural regulation.69,70 The association of DED with neurologic problems, such as neuropathic pain, chronic pain syndrome, peripheral neuropathy, and central nervous system manifestations, also has been documented by several investigators.2 
Patients with DED are Depressive
Depression as a comorbidity of DED has been described extensively, including in three systematic reviews and meta-analyses.2,3,7186 This is an important point, since depression is closely associated with sleep disorders.72,73 Zheng et al.3 reviewed the literature and reported that the highest prevalence of depression among ophthalmic patients was in those with DED (29%), followed by glaucoma (25%), age-related macular degeneration (24%), and cataract (23%), evaluated with the Beck Depression Inventory, Center for Epidemiologic Studies Depression Scale, and HADS. Wan et al.71 conducted a systematic review and meta-analysis of 22 studies that reported the prevalence, incidence, and/or severity grading of depression and/or anxiety in patients with DED. They reported that DED was associated with an increased prevalence of depression (OR, 2.92) and anxiety (OR, 2.80). Subgroup analyses revealed that the prevalence and severity of depression are greatest in pSS (described below). Certain antidepressants are anticholinergic and may worsen DED by suppressing lacrimal secretion.8790 Labbe et al.76 discussed the relationship between DED and depression. The symptoms of DED may induce depression and, in turn, depression and its medication might induce DED; additionally, they have common risk factors, such as female sex and age. Dysregulation of neuropeptides and an increased production of inflammatory cytokines also are present in both diseases. 
Sleep Disorders are a Common Comorbidity of pSS
Patients with pSS are affected by fatigue, daytime sleepiness, and insomnia. Several reports describe the pSS-related psychiatric status as sleep disorders, depression, and anxiety.91101 Sleep disorders in pSS are characterized as a long sleep latency and severe sleep difficulty due to pain. Ocular complications, such as the presence of sicca, have been surveyed in a few studies, however, no study has referred to ocular findings. 
Hackett et al.91 completed a systematic review of nine studies of sleep disturbances in pSS and concluded that a range of sleep disturbances are commonly reported in pSS patients; that is, prevalent night awakenings and increased obstructive sleep apnea in pSS compared to controls. In these studies, sleep disturbance was determined using sleep diaries, the Epworth Sleepiness Scale, the 15-item Dutch questionnaire on sleep quality, and polysomnography, and showed a longer sleep latency, short sleep duration, and low sleep efficacy in pSS. Sicca symptoms, nocturnal pain, and nocturia have been indicated as factors associated with sleep disorders in pSS. Recommended management strategies include cognitive behavioral therapy for insomnia, nocturnal humidification, and artificial saliva sprays. 
Priori et al.92 assessed the sleep quality, quality of life and mood disorders in patients with pSS using the PSQI, Short Form Health Survey 36, Functional Assessment of Chronic Illness Therapy fatigue scale, and HADS. The mean PSQI global score had higher pathologic values (8.6 ± 4.6) than in controls (5.6 ± 2.2). Additionally, the HADS subscales correlated with the PSQI subscales, while no correlation with the Functional Assessment of Chronic Illness Therapy fatigue scale or disease indexes emerged. 
Theander et al.93 studied the prevalence of fatigue and daytime sleepiness in pSS and concluded that fatigue is the main problem for patients with pSS, while sleepiness is a minor problem. Patients had significantly more frequent episodes of anxiety and nocturia and woke up more often during the night than controls. They described 13% of patients with pSS reported sicca symptoms disturbing sleep. 
Kok et al.100 reported a positive association between chronic sleep disorders and pSS (hazard ratio, 2.0) in a population-based longitudinal study. Valtysdottir et al.101 compared the Gothenburg quality of life instrument between pSS and rheumatoid arthritis and the patients with pSS had a significantly higher scoring rate for anxiety and also depression, compared to those with rheumatoid arthritis. Shen et al.98 reported that the adjusted hazard ratio of depressive, anxiety, and sleep disorders in patients with pSS was significantly higher at 1.829, 1.856, and 1.967, respectively, than those of controls during follow-up from 2000 to 2008. 
Ophthalmic Measures Followed by a Consultation-Liaison Psychiatry Service are Recommended for Sleep Disorders in DED
Ophthalmologists occasionally may encounter poor sleepers complaining of DED symptoms if the patient is a shift worker, nursing mother, or taking psychiatric medication. In addition to referring the patient to a psychiatrist, gynecologist, or other specialist for further management, they could treat DED with ophthalmic measures and the ocular improvement may lead to an advantageous effect on mood and sleep. One study evaluated the effect of topical medication on the sleep of patients with DED and suggested that a consultation-liaison psychiatry service (i.e., collaboration with psychiatrists and other medical specialists may be helpful for patients with DED and potential psychiatric problems).102 The study evaluated sleep quality in 71 patients with DED using a questionnaire-based survey before and after topical treatment for DED. The effectiveness of sleep and ophthalmic services in assisting with sleep problems in patients with eye disease was assessed using the PSQI and HADS. Significant improvement in the PSQI was found (P < 0.05) and strongly correlated with improvement in the HADS score for new patients (P < 0.05), but not for patients with established DED. A sleep service in this eye clinic has been opened and provides sleep hygiene, blue-light shield eyewear and wearable and desktop blue-light emitting lamps according to the patients' sleep problems. The service also prescribes melatonin agonist and sedative herbs. Another DED therapy reported to be effective for sleep and the autonomous nervous system is lid-heating during sleep.65,66,103,104 Sleep disorders and DED are common health problems in menopausal women and HRT has been proven effective for menopausal sleep disorders, however, it is controversial for DED.3440 Moreover, relieving the pain of DED may produce a reciprocal influence, since pain, sleep, and depression interact with each other.105,106 
Possible Explanation for Sleep Disorders in DED
A direct connection between DED and sleep has not been determined; however, an apparent association between sleep and depression,72,73 and between depression and DED has been well described in several reports. The current hypothesis for sleep disorders in DED is shown in the Figure. Firstly, depression may be considered as a possible causality in sleep disorders in DED. Several studies have demonstrated an association between the severity of sleep disorders, depression, and DED. Depression may induce DED and sleep disorders, and in turn, ocular diseases could induce depression, as reported in DED and glaucoma. The emotional burden due to the nature of the disease, and the medication burden could typically cause sleep disorders44,107 in ocular patients with depression.107111 Furthermore, DED often develops in glaucoma patients, since glaucoma medication is toxic to the ocular surface.112 Secondly, it is highly likely that pain113115 in patients with DED may be associated with sleep disorders. Sleep disorders with pain have been suggested in pSS and other rheumatic diseases.116 Pain is known to affect sleep quality in many diseases and a low threshold of pain is linked to sleep disorders.106,117 Thirdly, eye exposure may be frequent in patients with DED and this also could lead to sleep difficulty. DED, depression, and sleep disorders may be involved in a vicious spiral. 
Hypothesis for sleep disorders in patients with DED. Patients with DED may be distressed by sensory discomfort or optical disturbance, or have psychologic distress from the disease itself. During sleep, patients may feel pain and brightness during incomplete eye closure, producing inflammatory processes leading to sleep difficulty; this causes a vicious spiral of DED, depression, and sleep disorders.
Hypothesis for sleep disorders in patients with DED. Patients with DED may be distressed by sensory discomfort or optical disturbance, or have psychologic distress from the disease itself. During sleep, patients may feel pain and brightness during incomplete eye closure, producing inflammatory processes leading to sleep difficulty; this causes a vicious spiral of DED, depression, and sleep disorders.
Future Directions
The prevalence of DED and sleep disorders is increasing in modern society and these diseases have common exacerbating factors, including stress, a blue-light-rich environment, and 24-hour shift work. Research into sleep disorders in ocular patients has been historically performed by ophthalmologists and epidemiologists; however, involvement of psychiatrists and gynecologists should be further encouraged for a more comprehensive management. Objective methods, such as actigraphy, melatonin measurement, and polysomnography, would precisely confirm sleep quality in patients with DED. As DED is a multifactorial disease, multiple approaches also may be effective for sleep disorders in DED. Similarly, a psychiatric and neuronal approach may be simultaneously advantageous to both conditions. 
Sleep disorders are a serious health problem and ophthalmologists should be aware of the fact that DED in patients may be complicated by sleep and mood disorders. Although ophthalmologists may not be familiar with somnology, they should first listen to the patient (Sir William Osler, 1849–1919) to relieve them from distress. Then, they can use eye drops, other ophthalmic interventions, sleep hygiene, and psychiatric consultation to further alleviate their symptoms. 
Funding of the publication fee and administration was provided by the Dry Eye Society, Tokyo, Japan. The Dry Eye Society had no role in the contents or writing of the manuscript. 
Disclosure: M. Ayaki, None; K. Tsubota, None; M. Kawashima, None; T. Kishimoto, None; M. Mimura, None; K. Negishi, None 
Ayaki M, Kawashima M, Negishi K, Tsubota K. High prevalence of sleep and mood disorders in dry eye patients: survey of 1,000 eye clinic visitors. Neuropsychiatr Dis Treat. 2015; 11: 889–894.
Han SB, Yang HK, Hyon JY, Wee WR. Association of dry eye disease with psychiatric or neurological disorders in elderly patients. Clin Interv Aging. 2017; 12: 785–792.
Zheng Y, Wu X, Lin X, Lin H. The prevalence of depression and depressive symptoms among eye disease patients: a systematic review and meta-analysis. Sci Rep. 2017; 7: 46453.
Schaumberg DA, Dana R, Buring JE, Sullivan DA. Prevalence of dry eye disease among US men: estimates from the Physicians' Health Studies. Arch Ophthalmol. 2009; 127: 763–768.
Schaumberg DA, Sullivan DA, Buring JE, Dana MR. Prevalence of dry eye syndrome among US women. Am J Ophthalmol. 2003; 136: 318–326.
Rocha FL, Uchoa E, Guerra HL, Firmo JO, Vidigal PG, Lima-Costa MF. Prevalence of sleep complaints and associated factors in community-dwelling older people in Brazil: the Bambuí Health and Ageing Study (BHAS). Sleep Med. 2002; 3: 231–238.
Versura P, Campos EC. Menopause and dry eye. A possible relationship. Gynecol. Endocrinol. 2005: 20: 289–298.
Blask DE. Melatonin, sleep disturbance and cancer risk. Sleep Med Rev. 2009; 13: 257–264.
Kripke DF, Garfinkel L, Wingard DL, Klauber MR, Marler MR. Mortality associated with sleep duration and insomnia. Arch Gen Psychiatry. 2002; 59: 131–136.
Tamakoshi A, Ohno Y; JACC Study Group. Self-reported sleep duration as a predictor of all-cause mortality: result from the JACC Study, Japan. Sleep. 2004; 27: 51–54.
Garbarino S, Durando P, Guglielmi O, et al. Sleep apnea, sleep debt and daytime sleepiness are independently associated with road accidents. A cross-sectional study on truck drivers. PLoS One. 2016; 11: e0166262.
Kling RN. Sleep problems and workplace injuries in Canada. Sleep. 2010; 33: 611–618.
Stone KL, Blackwell TL, Ancoli-Israel S, et al. Sleep disturbances and risk of falls in older community-dwelling men: the outcomes of Sleep Disorders in Older Men (MrOS Sleep) Study. J Am Geriatr Soc. 2014; 62: 299–305.
Chang PP, Ford DE, Mead LA, Cooper-Patrick L, Klag MJ. Insomnia in young men and subsequent depression. The Johns Hopkins Precursors Study. Am J Epidemiol. 1997; 146: 105–114.
Kaneita Y, Kaneita Y, Ohida T, Uchiyama M, et al. The relationship between depression and sleep disturbance: a Japanese nation-wide general population survey. J Clin Psychiatry. 2006; 67: 196–203.
Nakajima H, Kaneita Y, Yokoyama E, et al. Association between sleep duration and hemoglobin A1c level. Sleep Med. 2008; 9: 745–752.
Watanabe M, Kikuchi H, Tanaka K, Takahashi M. Association of short sleep duration with weight gain and obesity at 1-year follow-up: a large-scale prospective study. Sleep. 2010; 33: 161–167.
Kaneita Y, Uchiyama M, Yoshiike N, Ohida T. Association of usual sleep duration and serum lipid and lipoprotein levels. Sleep. 2008; 31: 645–652
Gangwisch JE, Heymsfield SB, Boden-Albala B, et al. Short sleep duration as a risk factor for hypertension. Analyses of the First National Health and Nutrition Examination Survey. Hypertension. 2006; 47: 833–839.
Clerk A, Lange T, Hallqvist J, Jennum P, Rod NH. Sleep impairment and prognosis of acute myocardial infarction: a prospective cohort study. Sleep. 2014; 37: 851–858.
Cappuccio FP, Cooper D, D'Elia L, Strazzullo P, Miller MA. Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies. Eur Heart J. 2011; 32: 1484–1492.
Wittmann M, Dinich J, Merrow M, Roenneberg. Social jet lag: misalignment of biological and social time. Chronobiol Int. 2006; 23: 497–509.
Hyde M, O'Driscoll DM, Binette S, et al. Validation of actigraphy for determining sleep and wake in children with sleep disordered breathing. J Sleep Res. 2007; 16: 213–216.
Cole RJ, Kripke DF, Gruen W, Mullaney DJ, Gillin JC. Automatic sleep/wake identification from wrist activity. Sleep. 1992; 15: 461–469.
Czeisler CA, Shanahan TL, Klerman EB, et al. Suppression of melatonin secretion in some blind patients by exposure to bright light. N Engl J Med. 1995; 332: 6–11.
Buysse DJ, Reynolds CFIII, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatr Res. 1989; 28: 193–213.
Kravitz HM, Zhao X, Bromberger JT, et al. Sleep disturbance during the menopausal transition in a multi-ethnic community sample of women. Sleep. 2008: 31: 979–990.
Rosenberg R, Roach JM, Scharf M, Amato DA. A pilot study evaluating acute use of eszopiclone in patients with mild to moderate obstructive sleep apnea syndrome. Sleep Med. 2007; 8: 464–470.
Moser M, Schaumberger K, Schernhammer E, Stevens RG. Cancer and rhythm. Cancer Causes Control. 2006; 17: 483–487.
Campbell S, Whitehead M. Oestrogen therapy and the menopausal syndrome. Clin Obstet Gynecol. 1977; 4: 31–47.
Terauchi M, Obayashi S, Akiyoshi M, Kato K, Matsushima E, Kubota T. Insomnia in Japanese peri- and postmenopausal women. Climacteric. 2010; 13: 479–486.
Terauchi M, Hiramitsu S, Akiyoshi M, et al. Associations between anxiety, depression and insomnia in peri- and post-menopausal women. Maturitas. 2012; 72: 61–65.
Soares CN, Joffe H, Rubens R, Caron J, Roth T, Cohen L. Eszopiclone in patients with insomnia during perimenopause and early postmenopause: a randomized controlled trial. Obstet Gynecol. 2006; 108: 1402–1410.
Tal JT, Suh SA, Dowdle CL, Nowakowski S. Treatment of insomnia, insomnia symptoms, and sleep apnea during and after menopause: therapeutic approaches. Curr Psychiatry Rev. 2015; 11: 63–83.
Brown JP, Gallicchio L, Flaws JA, Tracy JK. Relations among menopausal symptoms, sleep disturbance and depressive symptoms in midlife. Maturitas. 2009; 62: 184–189.
Baker A, Simpson S, Dawson D. Sleep disruption and mood changes associated with menopause. J Psychosom Res. 1997; 43: 359–369.
Scuderi G, Contestabile MT, Gagliano C, Iacovello D, Scuderi L, Avitabile T. Effects of phytoestrogen supplementation in postmenopausal women with dry eye. Can J Ophthalmol. 2012; 47: 489–492.
Erdem U, Ozdegirmenci O, Sobaci E, Sobaci G, Göktolga U, Dagli S. Dry eye in post-menopausal women using hormone replacement therapy. Maturitas. 2007; 56: 257–262.
Feng Y, Feng G, Peng S, Li H. The effect of hormone replacement therapy on dry eye syndrome evaluated with Schirmer test and break-up time. J Ophthalmol. 2015; 2015: 420302.
Schaumberg DA, Buring JE, Sullivan DA, Dana MR. Hormone replacement therapy and dry eye syndrome. JAMA. 2001; 286: 2114–2119.
Saper CB, Scammell TE, Lu J. Hypothalamic regulation of sleep and circadian rhythms. Nature. 2005; 437: 1257–1263.
Panda S, Provencio I, Tu DC, et al. Melanopsin is required for non-image-forming photic responses in blind mice. Science. 2003; 301: 525–527.
Berson DM, Dunn FA, Takao M. Phototransduction by retinal ganglion cells that set the circadian clock. Science. 2002; 295: 1070–1073.
Gracitelli CP, Duque-Chica GL, Roizenblatt M, et al. Intrinsically photosensitive retinal ganglion cell activity is associated with decreased sleep quality in patients with glaucoma. Ophthalmology. 2015; 122: 1139–1148.
Erichsen JH, Brondsted AE, Kessel L. Effect of cataract surgery on regulation of circadian rhythms. J Cataract Refract Surg. 2015; 41: 1997–2009.
Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983; 67: 361–370.
Kawashima M, Uchino M, Yokoi N, et al. The association of sleep quality with dry eye disease: the Osaka study. Clin Ophthalmol. 2016; 10: 1015–1021.
Ayaki M, Kawashima M, Negishi K, Kishimoto T, Mimura M, Tsubota K. Sleep and mood disorders in women with dry eye disease. Sci Rep. 2016; 6: 35276.
Lee W, Lim SS, Won JU, et al. The association between sleep duration and dry eye syndrome among Korean adults. Sleep Med. 2015; 16: 1327–1331.
Ong ES, Alghamdi YA, Levitt RC, et al. Longitudinal examination of frequency of and risk factors for severe dry eye symptoms in US veterans. JAMA Ophthalmol. 2017; 135: 116–123.
Galor A, Seiden BE, Park JJ, et al. The association of dry eye symptom severity and comorbid insomnia in US veterans. Eye Contact Lens. 2018; 44 (suppl 1): S118–S124.
Hart FD, Taylor RT, Huskisson EC. Pain at night. Lancet. 1970; 295: 881–884.
Ayaki M, Kawashima M, Negishi K, Kishimoto T, Mimura M, Tsubota K. Sleep and mood disorders in dry eye disease and allied irritating ocular diseases. Sci Rep. 2016; 6: 22480.
Sack RA, Beaton A, Sathe S, Morris C, Willcox M, Bogart B. Towards a closed eye model of the pre-ocular tear layer. Prog Retin Eye Res. 2000; 19: 649–668.
Acera A, Vecino E, Duran JA. Tear MMP-9 levels as a marker of ocular surface inflammation in conjunctivochalasis. Invest Ophthalmol Vis Sci. 2013; 54: 8285–8291.
Galor A, Feuer W, Lee DJ, et al. Prevalence and risk factors of dry eye syndrome in a United States veterans affairs population. Am J Ophthalmol. 2011; 152: 377–384.
Karaca EE, Akçam HT, Uzun F, Özdek Ş, Ulukavak Çiftçi T. Evaluation of ocular surface health in patients with obstructive sleep apnea syndrome. Ophthalmol. 2016; 46: 103–108.
Acar M, Firat H, Yuceege M, Ardic S. Long-term effects of PAP on ocular surface in obstructive sleep apnea syndrome. Can J Ophthalmol. 2014; 49: 217–221.
Hayirci E, Yagci A, Palamar M, Basoglu OK, Veral A. The effect of continuous positive airway pressure treatment for obstructive sleep apnea syndrome on the ocular surface. Cornea. 2012; 31: 604–608.
Cartwright MJ, Frueh BR. Keratoconjunctivitis sicca in a patient with a Jones tube to treat sleep apnea. Am J Ophthalmol. 1992; 114: 234–235.
Gauba V, Curtis ZJ. Sleep position and the ocular surface in a high airflow environment. Saudi J Ophthalmol. 2014; 28: 66–68.
Alevi D, Perry HD, Wedel A, Rosenberg E, Alevi L, Donnenfeld ED. Effect of sleep position on the ocular surface. Cornea. 2017; 36: 567–571.
Asplund R. Nocturia in the elderly in relation to thirst, dry mouth and dry eyes. Can J Urol. 2004; 11: 2322–2326.
Lee YB, Koh JW, Hyon JY, Wee WR, Kim JJ, Shin YJ. Sleep deprivation reduces tear secretion and impairs the tear film. Invest Ophthalmol Vis Sci. 2014; 55: 3525–3331.
Kurihashi K. Moisture aid during sleep for the treatment of dry eye: wet gauze eye mask. Ophthalmologica. 1994; 208: 216–219.
Yamashiro Y, Igaki M, Sakamoto I, Suzuki A, Niki Y. Effect on sleep of the application of heat and steam generating sheets to the eyes [in Japanese]. Jpn J Physiol Anthropol. 2011; 16: 85–91.
Lindsley K, Matsumura S, Hatef E, Akpek EK. Interventions for chronic blepharitis. Cochrane Database Syst Rev. 2012; 5: CD005556.
Arita R, Morishige N, Sakamoto I, et al. Effects of a warm compress containing menthol on the tear film in healthy subjects and dry eye patients. Sci Rep. 2017; 7: 45848.
Stapleton F, Marfurt C, Golebiowski B, et al. The TFOS International Workshop on Contact Lens Discomfort: report of the subcommittee on neurobiology. Invest Ophthalmol Vis Sci. 2013; 54: TFOS71–TFOS97.
Dartt DA. Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases. Prog Retin Eye Res. 2009; 28: 155–177.
Wan KH, Chen LJ, Young AL. Depression and anxiety in dry eye disease: a systematic review and meta-analysis. Eye (Lond). 2016; 30: 1558–1567.
Breslau N, Roth T, Rosenthal L, Andreski P. Sleep disturbance and psychiatric disorders: a longitudinal epidemiological study of young adults. Biol Psychiatry. 1996; 39: 411–418.
Nutt D, Wilson S, Paterson L. Sleep disorders as core symptoms of depression. Dialogues Clin Neurosci. 2008; 10: 329–336.
Kim KW, Han SB, Han ER, et al. Association between depression and dry eye disease in an elderly population. Invest Ophthalmol Vis Sci. 2011; 52: 7954–7958.
van der Vaart R, Weaver MA, Lefebvre C, Davis RM. The association between dry eye disease and depression and anxiety in a large population-based study. Am J Ophthalmol. 2015; 159: 470–474.
Labbe A, Wang YX, Jie Y, Baudouin C, Jonas JB, Xu L. Dry eye disease, dry eye symptoms and depression: the Beijing Eye Study. Br J Ophthalmol. 2013; 97: 1399–1403.
Na KS, Han K, Park YG, Na C, Joo CK. Depression, stress, quality of life, and dry eye disease in Korean women: a population-based study. Cornea. 2015; 34: 733–738.
Szakats I, Sebestyen M, Nemeth J, Birkás E, Purebl G. The role of health anxiety and depressive symptoms in dry eye disease. Curr Eye Res. 2016; 41: 1044–1049.
Hallak JA, Tibrewal S, Jain S. Depressive symptoms in patients with dry eye disease: a case-control study using the beck depression inventory. Cornea. 2015; 34: 1545–1550.
Galor A, Feuer W, Lee DJ, et al. Depression, post-traumatic stress disorder, and dry eye syndrome: a study utilizing the national United States Veterans Affairs administrative database. Am J Ophthalmol. 2012; 154: 340–346.
Zhang Y, Lin T, Jiang A, Zhao N, Gong L. Vision-related quality of life and psychological status in Chinese women with Sjögren's syndrome dry eye: a case-control study. BMC Womens Health. 2016; 16: 75.
Lutgendorf SK, Garand L, Buckwalter KC, Reimer TT, Hong SY, Lubaroff DM. Life stress, mood disturbance, and elevated interleukin-6 in healthy older women. J Gerontol A Biol Sci Med Sci. 1999; 54: M434–M439.
Miljanovic B, Trivedi KA, Dana MR, Gilbard JP, Buring JE, Schaumberg DA. Relation between dietary n-3 and n-6 fatty acids and clinically diagnosed dry eye syndrome in women. Am J Clin Nutr. 2005; 82: 887–893.
Liyue H, Chiang PP, Sung SC, Tong L. Dry eye-related visual blurring and irritative symptoms and their association with depression and anxiety in eye clinic patients. Curr Eye Res. 2016; 41: 590–599.
Li M, Gong L, Sun X, Chapin WJ. Anxiety and depression in patients with dry eye syndrome. Curr Eye Res. 2011; 36: 1–7.
Wen W, Wu Y, Chen Y, et al. Dry eye disease in patients with depressive and anxiety disorders in Shanghai. Cornea. 2012; 31: 686–692.
Wilson K, Mottram P. A comparison of side effects of selective serotonin reuptake inhibitors and tricyclic antidepressants in older depressed patients: a meta-analysis. Int J Geriatr Psychiatry. 2004; 19: 754–762.
Ghaffariyeh A, Chamacham T. Tricyclic antidepressants: potential therapeutic alternatives for treatment of dry eye symptoms after LASIK. J Refract Surg. 2008; 24: 770–771
Mrugacz M, Ostrowska L, Łazarczyk-Kirejczyk J, et al. Dry eye disease in patients treated with antidepressants [in Polish]. Klin Oczna. 2013; 115: 111–114.
Kocer E, Kocer A, Ozsutcu M, Dursun AE, Krpnar I. Dry eye related to commonly used new antidepressants. J Clin Psychopharmacol. 2015; 35: 411–413.
Hackett KL, Gotts ZM, Ellis J, et al. An investigation into the prevalence of sleep disturbances in primary Sjögren's syndrome: a systematic review of the literature. Rheumatology (Oxford). 2017; 56: 570–580.
Priori R, Minniti A, Antonazzo B, Fusconi M, Valesini G, Curcio G. Sleep quality in patients with primary Sjögren's syndrome. Clin Exp Rheumatol. 2016; 34: 373–379.
Theander L, Strömbeck B, Mandl T, Theander E. Sleepiness or fatigue? Can we detect treatable causes of tiredness in primary Sjögren's syndrome? Rheumatology (Oxford). 2010; 49: 1177–1183.
Tishler M, Barak Y, Paran D, Yaron M. Sleep disturbances, fibromyalgia and primary Sjögren's syndrome. Clin Exp Rheumatol. 1997; 15: 71–74.
Gudbjörnsson B, Broman JE, Hetta J, Hällgren R. Sleep disturbances in patients with primary Sjögren's syndrome. Br J Rheumatol. 1993; 32: 1072–1076.
George A, Pope JE. The minimally important difference (MID) for patient-reported outcomes including pain, fatigue, sleep and the health assessment questionnaire disability index (HAQ-DI) in primary Sjögren's syndrome. Clin Exp Rheumatol. 2011; 29: 248–253.
Karageorgas T, Fragioudaki S, Nezos A, Karaiskos D, Moutsopoulos HM, Mavragani CP. Fatigue in primary Sjögren's syndrome: clinical, laboratory, psychometric, and biologic associations. Arthritis Care Res (Hoboken). 2016; 68: 123–131.
Shen CC, Yang AC, Kuo BI, Tsai SJ. Risk of psychiatric disorders following primary Sjögren syndrome: a nationwide population-based retrospective cohort study. J Rheumatol. 2015; 42: 1203–1208.
Usmani ZA, Hlavac M, Rischmueller M, et al. Sleep disordered breathing in patients with primary Sjögren's syndrome: a group controlled study. Sleep Med. 2012; 13: 1066–1070.
Kok VC, Horng JT, Hung GD, et al. Risk of autoimmune disease in adults with chronic insomnia requiring sleep-inducing pills: a population-based longitudinal study. J Gen Intern Med. 2016; 31: 1019–1026.
Valtysdottir ST, Gudbjornsson B, Lindqvist U, Hallgren R, Hetta J. Anxiety and depression in patients with primary Sjogren's syndrome. J Rheumatol. 2000; 27: 165–169.
Ayaki M, Toda I, Tachi N, Negishi K, Tsubota K. Preliminary report of improved sleep quality in patients with dry eye disease after initiation of topical therapy. Neuropsychiatr Dis Treat. 2016; 12: 329–337.
Ochiai R. Moist heat stimulation influence on electroencephalograms and the autonomic nervous system [in Japanese]. Auton Nerv Syst. 2001; 38: 450–454.
Takamoto K, Hori E, Urakawa S, et al. Thermotherapy to the facial region in and around the eyelids altered prefrontal hemodynamic responses and autonomic nervous activity during mental arithmetic. Psychophysiology. 2013; 50: 35–47.
Kroenke K, Wu JW, Bair MJ, Krebs EE, Damush TM, Tu W. Reciprocal relationship between pain and depression: a 12-month longitudinal analysis in primary care. J Pain. 2011; 12: 964–973.
Sivertsen B, Lallukka T, Petrie KJ, Steingrímsdóttir ÓA, Stubhaug A, Nielsen CS. Sleep and pain sensitivity in adults. Pain. 2015; 156: 1433–1439.
Ayaki M, Shiba D, Negishi K, Tsubota K. Depressed visual field and mood are associated with sleep disorder in glaucoma patients. Sci Rep. 2016; 6: 25699.
Agorastos A, Skevas C, Matthaei M, et al. Depression, anxiety, and disturbed sleep in glaucoma. J Neuropsychiatry Clin Neurosci. 2013; 25: 205–213.
Mabuchi F, Yoshimura K, Kashiwagi K, et al. Risk factors for anxiety and depression in patients with glaucoma. Br J Ophthalmol. 2012; 96: 821–825.
Kong X, Yan M, Sun X, Xiao Z. Anxiety and depression are more prevalent in primary angle closure glaucoma than in primary open-angle glaucoma. J Glaucoma. 2015; 24: e57–e63.
Kong XM, Zhu WQ, Hong JX, Sun XH. Is glaucoma comprehension associated with psychological disturbance and vision-related quality of life for patients with glaucoma? A cross-sectional study. BMJ Open. 2014; 4: e004632.
Iwasawa A, Ayaki M, Niwano Y. Cell viability score (CVS) as a good indicator of critical concentration of benzalkonium chloride for toxicity in cultured ocular surface cell lines. Regul Toxicol Pharmacol. 2013; 66: 177–183.
Rosenthal P, Borsook D. Ocular neuropathic pain. Br J Ophthalmol. 2016; 100: 128–134.
McMonnies CW. The potential role of neuropathic mechanisms in dry eye syndromes. J Optom. 2017; 10: 5–13.
Galor A, Levitt RC, Felix ER, Martin ER, Sarantopoulos CD. Neuropathic ocular pain: an important yet underevaluated feature of dry eye. Eye (Lond). 2015; 29: 301–312.
Abad VC, Sarinas PS, Guilleminault C. Sleep and rheumatologic disorders. Sleep Med Rev. 2008; 12: 211–228.
Finan PH, Goodin BR, Smith MT. The association of sleep and pain: an update and a path forward. J Pain. 2013; 14: 1539–1552.
Hypothesis for sleep disorders in patients with DED. Patients with DED may be distressed by sensory discomfort or optical disturbance, or have psychologic distress from the disease itself. During sleep, patients may feel pain and brightness during incomplete eye closure, producing inflammatory processes leading to sleep difficulty; this causes a vicious spiral of DED, depression, and sleep disorders.
Hypothesis for sleep disorders in patients with DED. Patients with DED may be distressed by sensory discomfort or optical disturbance, or have psychologic distress from the disease itself. During sleep, patients may feel pain and brightness during incomplete eye closure, producing inflammatory processes leading to sleep difficulty; this causes a vicious spiral of DED, depression, and sleep disorders.
Studies Evaluating Dry Eye and Sleep
Studies Evaluating Dry Eye and Sleep

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