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Peyman Davvalo Khongar, Jan O. Pralits, Xi Cheng, Peter Pinsky, Paolo Soleri, Rodolfo Repetto; A Mathematical Model of Corneal Metabolism in the Presence of an Iris-Fixated Phakic Intraocular Lens. Invest. Ophthalmol. Vis. Sci. 2019;60(6):2311-2320. doi: https://doi.org/10.1167/iovs.19-26624.
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Corneal endothelial cell loss is one of the possible complications associated with phakic iris-fixated intraocular lens (PIOL) implantation. We postulate that this might be connected to the alteration of corneal metabolism secondary to the lens implantation.
A mathematical model of transport and consumption/production of metabolic species in the cornea is proposed, coupled with a model of aqueous flow and transport of metabolic species in the anterior chamber.
Results are presented both for open and closed eyelids. We showed that, in the presence of a PIOL, glucose availability at the corneal endothelium decreases significantly during sleeping.
Implantation of a PIOL significantly affects nutrient transport processes to the corneal endothelium especially during sleep. It must still be verified whether this finding has a clinical relevance.
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