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Miryoung Song, Jae Suk Kim, Je Hyung Hwang, Won Hyuk Oh, Jae Yong Park, BUMGI KIM; Volume evaluation of additional Anti-VEGF agents released when the plunger is double squeezed. Invest. Ophthalmol. Vis. Sci. 2019;60(9):113.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the accuracy of different syringe for intravitreal injection of anti-VEGF agents and volume of additional Anti-VEGF agents released when the plunger is double squeezed
Volume output was measured from two syringe—1) 1.0 mL tuberculin syringe, 2) 1.0 mL luer lock syringe—to deliver 50 μL of bevacizumab, each repeated by one physician for 100 total simulated injections. Volume output was calculated from difference in syringe weight before and after expelling the drug. Volume of additional Anti-VEGF agents released is obtained by pressing the plunger with additional force after the plunger tip is depressed 0 on the syringe. Volume analysis was compared using t-test.
The measured volume at the first injection was 52.8 ± 3.6 μL for the tuberculin syringe, 46.5 ± 2.8 μL for the luer lock syringe, and the additional volume released was 32.3 ± 11.2 μL for the tuberculin syringe and 47.2± 8.0 μL. There was no significant difference between the syringes measured at the first injection(p>0.01). Also, the additional measured volume was not significantly different between syringes(p>0.01)
There is no significant difference in the injection volume per syringe. Prevention of underdosing in intravitreal injection can be obtained by applying more force after the plunger tip is located at zero.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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