July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Evaluation of foveal avascular zone and macular vessel density in unilateral amblyopia using optical coherence tomographic angiography
Author Affiliations & Notes
  • Atsushi Miki
    Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Okayama, Japan
  • Syunsuke Araki
    Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Okayama, Japan
  • Katsutoshi Goto
    Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Okayama, Japan
  • Tsutomu Yamashita
    Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Okayama, Japan
  • Tsuyoshi Yoneda
    Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Okayama, Japan
  • Kazuko Haruishi
    Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Okayama, Japan
  • Yoshiaki Ieki
    Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Okayama, Japan
  • Junichi Kiryu
    Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Okayama, Japan
  • Goro Maehara
    Department of Human Sciences, Kanagawa University, Yokohama, Kanagawa, Japan
  • Kiyoshi Yaoeda
    Yaoeda Eye Clinic, Nagaoka, Niigata, Japan
  • Footnotes
    Commercial Relationships   Atsushi Miki, None; Syunsuke Araki, None; Katsutoshi Goto, None; Tsutomu Yamashita, None; Tsuyoshi Yoneda, None; Kazuko Haruishi, None; Yoshiaki Ieki, None; Junichi Kiryu, None; Goro Maehara, None; Kiyoshi Yaoeda, None
  • Footnotes
    Support  The Japan Society for the Promotion of Science (JSPS) KAKENHI Grants-in-Aid Grant Number 17K04506
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 209. doi:
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      Atsushi Miki, Syunsuke Araki, Katsutoshi Goto, Tsutomu Yamashita, Tsuyoshi Yoneda, Kazuko Haruishi, Yoshiaki Ieki, Junichi Kiryu, Goro Maehara, Kiyoshi Yaoeda; Evaluation of foveal avascular zone and macular vessel density in unilateral amblyopia using optical coherence tomographic angiography. Invest. Ophthalmol. Vis. Sci. 2019;60(9):209.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate foveal avascular zone (FAZ) area and macular vessel density (VD) in unilateral amblyopia using OCT angiography (OCTA).

Methods : Fifteen patients with unilateral amblyopia due to anisometropia or anisometropia combined with strabismus (age: 9.8 ± 3.4 years, 6 to 17 years; four male, eleven female) were enrolled. The visual acuity (log MAR) was 0.21 ± 0.24 in the amblyopic eyes and -0.17 ± 0.03 in the fellow eyes. The refraction (diopters) was 5.13 ± 2.54 in the amblyopic eyes and 1.05 ± 1.96 in the fellow eyes. OCTA images were obtained by using the spectral-domain (SD)-OCT with an angiography software (RS-3000 Advance with AngioScan2 software; NIDEK, Gamagori, Japan). The OCTA scanning protocol used was 3 × 3 mm volume scan centered on the fovea using the tracing HD function to track eye movements. The data from SD-OCT were corrected for the magnification error using individual axial length using a built-in software. The averaged FAZ areas of two manual measurements by two examiners, macular VD calculated using ImageJ software (NIH, Bethesda, USA), and foveal minimum thickness (FMT) measured by the built-in automatic analysis software on the RS-3000 Advance were used for the analysis. The FAZ areas and macular VD in both superficial capillary plexus (SCP) and deep capillary plexus (DCP) layers were evaluated. The VD (%) was calculated by the following formula: VD (%) = vascular area (pixels) / (total scan area – FAZ area) (pixels) × 100. An unpaired t-test was used to compare the mean values of each parameter between the amblyopic and fellow eyes. Intraclass correlation coefficient (ICC) was used for the assessment of inter-rater reliability of FAZ area measurements.

Results : Inter-rater reliability was excellent for FAZ area measurements (ICC: 0.96, p < 0.001). The values for the amblyopic eyes v.s. the fellow eyes were as follows: FAZ area (SCP: 0.34 ± 0.09 mm2 v.s. 0.36 ± 0.08 mm2 , p = 0.49; DCP: 0.42 ± 0.13 mm2 v.s. 0.41 ± 0.09 mm2 , p = 0.81), macular VD (SCP: 36.68 ± 0.37% v.s. 36.49 ± 0.58%, p = 0.29; DCP: 39.92 ± 0.46% v.s. 39.86 ± 0.45%, p = 0.70), and FMT (227.9 ± 20.5 μm v.s. 221.2 ± 10.3 μm, p = 0.27). There was no significant difference (p > 0.05) in any of the parameters between the amblyopic and fellow eyes.

Conclusions : Our findings suggest that macular retinal vasculature is not significantly altered in unilateral amblyopia.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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