July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Inverse occlusion, a binocularly motivated treatment for amblyopia
Author Affiliations & Notes
  • Jiawei Zhou
    Ophthalmology, Wenzhou Medical University, Wenzhou, China
  • Yidong Wu
    Ophthalmology, Wenzhou Medical University, Wenzhou, China
  • Yiya Chen
    Ophthalmology, Wenzhou Medical University, Wenzhou, China
  • Xiaoxin Chen
    Ophthalmology, Wenzhou Medical University, Wenzhou, China
  • Yunjie Liang
    Ophthalmology, Wenzhou Medical University, Wenzhou, China
  • Yu Mao
    Ophthalmology, Wenzhou Medical University, Wenzhou, China
  • Zhimo Yao
    Ophthalmology, Wenzhou Medical University, Wenzhou, China
  • Zhifen He
    Ophthalmology, Wenzhou Medical University, Wenzhou, China
  • Fan Lu
    Ophthalmology, Wenzhou Medical University, Wenzhou, China
  • Jia Qu
    Ophthalmology, Wenzhou Medical University, Wenzhou, China
  • Robert Hess
    Ophthalmology, McGill University, Quebec, Canada
  • Footnotes
    Commercial Relationships   Jiawei Zhou, None; Yidong Wu, None; Yiya Chen, None; Xiaoxin Chen, None; Yunjie Liang, None; Yu Mao, None; Zhimo Yao, None; Zhifen He, None; Fan Lu, None; Jia Qu, None; Robert Hess, None
  • Footnotes
    Support  This work was supported by the National Natural Science Foundation of China grant NSFC 81500754, the Qianjiang Talent Project (QJD1702021), the Wenzhou Medical University grant QTJ16005 and a grant from the Ministry of Human Resources and Social Security, China to JZ, the Canadian Institutes of Health Research Grants CCI-125686 and 228103, and an ERA-NET Neuron grant (JTC2015) to RFH, and the Natural Science Foundation of Zhejiang Province Grant (LQ18C090002) to ZY.
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 214. doi:https://doi.org/
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      Jiawei Zhou, Yidong Wu, Yiya Chen, Xiaoxin Chen, Yunjie Liang, Yu Mao, Zhimo Yao, Zhifen He, Fan Lu, Jia Qu, Robert Hess; Inverse occlusion, a binocularly motivated treatment for amblyopia. Invest. Ophthalmol. Vis. Sci. 2019;60(9):214. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Recent laboratory finding suggest that short-term patching the amblyopic eye (i.e., inverse occlusion) results in a larger and more sustained improvement in the binocular balance compared with normal controls. In this study, we investigate the cumulative effects of the short-term inverse occlusion in adults and old children with amblyopia.

Methods : A prospective cohort study of 18 amblyopes (10-35 years old; 3 with strabismus) who have been subjected to 2 hours/day of inverse occlusion for 2 months. Patients who required refractive correction or whose refractive correction needed updating were given a 2-month period of refractive adaptation. The primary outcome measure was the binocular balance which was measured using a phase combination task, the secondary outcome measures were the best corrected visual acuity which was measured with a Tumbling E acuity chart and convert to logMAR units and the stereo acuity which was measured with the Random-dot preschool stereotest.

Results : The averaged binocular gain was 0.11 in terms of the effective contrast ratio (z = -2.344, p= 0.019, 2-tailed Related samples Wilcoxon Signed Ranks Test). The average acuity gain was 0.13 logMAR equivalent (t(17) = 4.76, p< 0.001, 2-tailed paired samples t-test). The averaged stereo acuity gain was 339 arc seconds (z = -2.533, p= 0.011).

Conclusions : Based on more recent research concerning adult ocular dominance plasticity, we conclude that inverse occlusion in adults and old children with amblyopia does produce long term gains to binocular balance and that acuity and stereopsis can improve in some subjects.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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