July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Satellite Cell Activity in Extraocular Muscle after Recession and Resection
Author Affiliations & Notes
  • Suk-Gyu Ha
    Ophthalmology, Korea University, College of Medicine , Guro-gu, Korea (the Republic of)
  • Jin-Hwan Park
    Ophthalmology, Korea University, College of Medicine , Guro-gu, Korea (the Republic of)
  • Seung-Hyun Kim
    Ophthalmology, Korea University, College of Medicine , Guro-gu, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Suk-Gyu Ha, None; Jin-Hwan Park, None; Seung-Hyun Kim, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 241. doi:
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    • Get Citation

      Suk-Gyu Ha, Jin-Hwan Park, Seung-Hyun Kim; Satellite Cell Activity in Extraocular Muscle after Recession and Resection. Invest. Ophthalmol. Vis. Sci. 2019;60(9):241.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the effects of recession and resection surgery of extraocular muscle (EOM) on satellite cell activity in rabbit

Methods : Sixteen eyes of 8 rabbits were included in this study. The superior rectus in the right eye was recessed or resected. Recession and resection surgery performed in 4 and 4 rabbits, respectively. Recession and resection surgery were performed at 5 (2 rabbits) and 10 mm (2 rabbits) and at 4 (2 rabbits) and 8 mm (2 rabbits) from original insertion, respectively. The superior rectus (operated muscle), inferior rectus (antagonist muscle) and superior rectus in the contralateral eye (control) were extracted after 4 weeks of operation. PAX7 activity was measured by immunohistochemistry analysis. Myf5 and MyoG expression were analyzed by real-time polymerase chain reaction.

Results : PAX7 activity in operated muscle was higher than that in antagonist muscle (p < 0.01). PAX7 activity in operated and antagonist muscle after resection surgery was higher than after recession surgery (p = 0.03, 0.02). Myf5 and MyoG expression in operated muscle was higher than that in antagonist muscle (p = 0.02, < 0.01, respectively). Myf5 and MyoG expression in operated muscle after resection surgery were higher than those after recession surgery (p = 0.02, 0.04). There was no significant difference of Myf5 expression after recession and resection surgery in antagonist muscle (p = 0.65). There was no significant difference of MyoG expression after recession and resection surgery in antagonist muscle (p = 0.35).

Conclusions : Activation and regeneration of satellite cell in operated and antagonist muscle after resection surgery increased more than those after recession surgery. These changes in satellite cells of EOM may explain postoperative alignment of EOM after strabismus surgery.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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