Abstract
Purpose :
Ozonated water produces oxygen in the water, and it is applied in various fields due to its antibacterial action; however, there is no report about its oxygen-supply action in the cornea. This study aimed to investigate the efficacy of topical administered ozonated water to supply oxygen to the porcine cornea.
Methods :
Change in the oxygen partial pressure in the cornea was measured by inserting an oxygen-sensitive measurement probe in the porcine cornea at an interval of 15 seconds for total 3 minutes. The porcine corneas included in the study were assigned to six groups comprising three each: the untreated cornea group (control group), epithelial stripping group, oxygen masking group, epithelial stripping with oxygen masking group, topical administrated ozonated water group, epithelial stripping with topical ozonated water group. The mean oxygen partial pressure in the cornea was compared between groups.
Results :
The mean oxygen partial pressure was 150.0mmHg in the control group, 152.8 mmHg in the epithelial stripping group, 153.5 mmHg in oxygen masking group, 153.8 mmHg in epithelial stripping with oxygen masking group, 156.7 mmHg in topical administrated ozonated water group, 158.4 mmHg in epithelial stripping with topical ozonated water. The mean oxygen partial pressure was significantly increased in all groups in comparison with that in the control group (p＜0.05), and significantly increased in the ozonated water group in comparison with that in the epithelial stripping with oxygen masking group (p＜0.05).
Conclusions :
The administration of ozonated water increased the oxygen partial pressure in the cornea, which may enable a better regimen with shortened operation time and more effectiveness due to utilization of the corneal oxygen in corneal cross-linking.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.