July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Incidence of age-related macular degeneration in the central region of Portugal: the Coimbra Eye Study – report 5
Author Affiliations & Notes
  • Claudia Farinha
    AIBILI, Coimbra, Portugal
    Ohthalmology Department, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal
  • Maria Luz Cachulo
    AIBILI, Coimbra, Portugal
    Ohthalmology Department, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal
  • Dalila Alves
    AIBILI, Coimbra, Portugal
  • Isabel Pires
    AIBILI, Coimbra, Portugal
    Ohthalmology Department, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal
  • Jo�o Pedro Marques
    AIBILI, Coimbra, Portugal
    Ohthalmology Department, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal
  • Patricia Barreto
    AIBILI, Coimbra, Portugal
  • Sandrina Nunes
    AIBILI, Coimbra, Portugal
  • Jose Costa
    AIBILI, Coimbra, Portugal
  • Amelia Martins
    AIBILI, Coimbra, Portugal
    Ohthalmology Department, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal
  • Isa Sobral
    AIBILI, Coimbra, Portugal
    Ohthalmology Department, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal
  • Ines Lains
    Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Joao Figueira
    AIBILI, Coimbra, Portugal
    Ohthalmology Department, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal
  • Maria Luisa Ribeiro
    AIBILI, Coimbra, Portugal
  • Jose G Cunha-Vaz
    AIBILI, Coimbra, Portugal
    Faculty of Medicine, University of Coimbra, Coimbra, Portugal
  • Rufino Silva
    AIBILI, Coimbra, Portugal
    Ohthalmology Department, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal
  • Footnotes
    Commercial Relationships   Claudia Farinha, None; Maria Luz Cachulo, None; Dalila Alves, None; Isabel Pires, None; Jo�o Pedro Marques, None; Patricia Barreto, None; Sandrina Nunes, None; Jose Costa, None; Amelia Martins, None; Isa Sobral, None; Ines Lains, None; Joao Figueira, Alcon (C), Alimera (C), Allergan (C), Bayer (C), Novartis (C), Pfizer (C); Maria Luisa Ribeiro, None; Jose Cunha-Vaz, Alimera (C), Allergan (C), Bayer (C), Carl Zeiss Meditec (C), Gene Signal (C), Novartis (C), Pfizer (C), Precision Ocular Ltd (C), Roche (C), Sanofi - Aventis (C), Vifor Pharma (C); Rufino Silva, Alcon (C), Alimera Sciences (C), Allergan (C), Bayer (C), Novartins (C), Thea (C)
  • Footnotes
    Support  Novartis Grant
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 58. doi:https://doi.org/
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      Claudia Farinha, Maria Luz Cachulo, Dalila Alves, Isabel Pires, Jo�o Pedro Marques, Patricia Barreto, Sandrina Nunes, Jose Costa, Amelia Martins, Isa Sobral, Ines Lains, Joao Figueira, Maria Luisa Ribeiro, Jose G Cunha-Vaz, Rufino Silva; Incidence of age-related macular degeneration in the central region of Portugal: the Coimbra Eye Study – report 5. Invest. Ophthalmol. Vis. Sci. 2019;60(9):58. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : AMD is the leading cause of irreversible visual impairment in the elderly in developed countries, therefore, incidence population-based studies in AMD are vital in planning for demand in health care systems. The purpose of this study is to describe the 6.5-year incidence and progression of early and late AMD in a coastal town in the central region of Portugal.

Methods : Population-based cohort study. Participants underwent standardized interviews and ophthalmologic examination, including digital fundus imaging. Colour fundus photographs were graded according to the International Classification and Grading System for AMD and ARM from the International ARM Epidemiological Study Group. The crude and age-standardized incidence of early and late AMD was calculated, and progression was analysed.

Results : The overall 6.5-year cumulative incidence of early AMD was 10.7%, and that of late AMD was 0.8%. The incidence of early AMD was 7.2%, 13.1% and 17.7%, for participants aged 55 to 64 years, 65 to 74 years and 75 to 84 years (p<0.001). Late AMD incidence was 0.3%, 0.9% and 2.8% for the corresponding age groups (p=0.003). Age-standardized incidence was 10.8% (95%CI, 10.74%-10.80%) for early and 1.0% (95%CI, 1.00%-1.02%) for late AMD. The incidence of NV-AMD and GA was 0.4%, for both late forms. Progression was found in 17.2% of patients.

Conclusions : This study documents the incidence and progression of AMD in a coastal town in central Portugal, a Mediterranean country from Southern Europe. Early AMD incidence was found to be similar to major epidemiologic studies of European-descent populations, however the incidence of late AMD was lower suggesting the value of further analysis of genetic, nutritional and environmental risk factors in this population.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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