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Donghoon SHIN, Don-Il Ham; Clinical Manifestation of Cuticular Drusen in Korean Patients. Invest. Ophthalmol. Vis. Sci. 2019;60(9):65.
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© ARVO (1962-2015); The Authors (2016-present)
Cuticular drusen has been studied mainly in white people. To investigate possible ethnic difference in cuticular drusen, clinical manifestation was analyzed in Korean patients.
Medical records and imaging data of 94 Korean patients diagnosed as cuticular drusen were retrospectively reviewed. All patients underwent complete ophthalmologic examinations including best corrected visual acuity (BCVA), color fundus photography, and fluorescein angiography. Optical coherence tomography and fundus autofluorescence imaging were also performed. Distribution pattern in the fundus, presence of acquired vitelliform lesions (AVLs), choroidal neovascularization (CNV) and geographic atrophy (GA) were analyzed. Data were compared with previously reported data in the white people.
The mean age was 66.9 ± 9.1 years (range, 26 – 87 years), and mean BCVA was 0.14 ± 0.26 logarithm of the minimum angle of resolution (logMAR). 75 patients (80.0%) were females. All patients had bilateral, symmetric subretinal pigment epithelial deposits, showing hyperfluorescence on FA. The location of cuticular drusen was confined to the central region in 34.0%, the peripheral region in 11.7%, and both regions in 54.3% of eyes. AVLs, CNV, GA were observed in 2 eyes (1.1%), in 6 eyes (3.2%), and in 30 eyes (16.0%) respectively, which were less than previously reported rate in the white people. Presence of AVLs, CNV, and GA were associated with worse BCVA in eyes with the cuticular drusen phenotype (p = 0.001, 0.008, 0.001, respectively).
Vitelliform lesion and advanced age-related macular degeneration are less frequently observed in Korean cuticular drusen patients than in the white ethnic group.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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