Subretinal drusenoid deposits in the elderly in a population-based study (the Montrachet study: Maculopathy, Optic Nerve, nuTRition, neurovAsCular and HEarT diseases)

Abstract

Purpose : The aim of this study was to investigate the prevalence of subretinal drusenoid deposits (SDD) and to identify associated factors in an elderly population.

Methods : The participants of the population-based Montrachet (Maculopathy Optic Nerve, nuTRition neurovAsCular and HEarT) study underwent an exhaustive ophthalmologic examination, including color fundus photography and macular spectral domain-optical coherence tomography coupled with infrared reflectance imaging. The presence of SDD, ellipsoid zone integrity and subfoveal choroidal thickness (SFCT) were recorded. Meanwhile, the association of SDD and both clinical and demographic factors and plasma levels of Vitamin E and Lutein/Zeaxanthine (L/Z) were analysed using general estimating equation multivariate logistic models.

Results : The mean age was 82.3 ± 3.8 years and 62.7% were female. The prevalence of SDD was 18.1% (n=205) in the subjects with at least one eye interpretable (n=1135). In multivariate analysis, SDD was positively associated with increasing age (OR, 4.6; 95% CI, 2.8-7.7; P < 0.001 for subjects aged >85 years old), female gender (OR, 1.7; 95% CI, 1.2-2.4; P = 0.005) and plasma L/Z level (OR, 1.2; 95% CI, 1.0-1.5; P = 0.039), and negatively associated with lipid-lowering drugs use (OR, 0.5; 95% CI, 0.3-0.9; P = 0.014 for statin medications) and SFCT (OR, 0.8; 95% CI, 0.7-0.9; P = 0.002).

Conclusions : The prevalence of SDD was high in subjects older than 75 years old. We reported demographic, clinical and biological factors associated with SDD.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.