July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Subretinal drusenoid deposits in the elderly in a population-based study (the Montrachet study: Maculopathy, Optic Nerve, nuTRition, neurovAsCular and HEarT diseases)
Author Affiliations & Notes
  • Pierre-Henry GABRIELLE
    Ophthalmology department, Dijon University Hospital, Dijon, France
    Eye and Nutrition Research Group, CSGA, UMR 1324 INRA, 6265 CNRS, Dijon, France
  • Alassane Seydou
    Department of Epidemiology, INSERM unit,, Dijon University Hospital, Dijon, France
  • Louis Arnould
    Ophthalmology department, Dijon University Hospital, Dijon, France
  • Niyazi Acar
    Eye and Nutrition Research Group, CSGA, UMR 1324 INRA, 6265 CNRS, Dijon, France
  • Christine Binquet
    Department of Epidemiology, INSERM unit,, Dijon University Hospital, Dijon, France
  • Alain M Bron
    Ophthalmology department, Dijon University Hospital, Dijon, France
    Eye and Nutrition Research Group, CSGA, UMR 1324 INRA, 6265 CNRS, Dijon, France
  • Catherine Creuzot-Garcher
    Ophthalmology department, Dijon University Hospital, Dijon, France
    Eye and Nutrition Research Group, CSGA, UMR 1324 INRA, 6265 CNRS, Dijon, France
  • Footnotes
    Commercial Relationships   Pierre-Henry GABRIELLE, None; Alassane Seydou, None; Louis Arnould, None; Niyazi Acar, None; Christine Binquet, None; Alain Bron, None; Catherine Creuzot-Garcher, None
  • Footnotes
    Support  an interregional grant (PHRC) and the regional Council of Burgundy
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 66. doi:https://doi.org/
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      Pierre-Henry GABRIELLE, Alassane Seydou, Louis Arnould, Niyazi Acar, Christine Binquet, Alain M Bron, Catherine Creuzot-Garcher; Subretinal drusenoid deposits in the elderly in a population-based study (the Montrachet study: Maculopathy, Optic Nerve, nuTRition, neurovAsCular and HEarT diseases). Invest. Ophthalmol. Vis. Sci. 2019;60(9):66. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The aim of this study was to investigate the prevalence of subretinal drusenoid deposits (SDD) and to identify associated factors in an elderly population.

Methods : The participants of the population-based Montrachet (Maculopathy Optic Nerve, nuTRition neurovAsCular and HEarT) study underwent an exhaustive ophthalmologic examination, including color fundus photography and macular spectral domain-optical coherence tomography coupled with infrared reflectance imaging. The presence of SDD, ellipsoid zone integrity and subfoveal choroidal thickness (SFCT) were recorded. Meanwhile, the association of SDD and both clinical and demographic factors and plasma levels of Vitamin E and Lutein/Zeaxanthine (L/Z) were analysed using general estimating equation multivariate logistic models.

Results : The mean age was 82.3 ± 3.8 years and 62.7% were female. The prevalence of SDD was 18.1% (n=205) in the subjects with at least one eye interpretable (n=1135). In multivariate analysis, SDD was positively associated with increasing age (OR, 4.6; 95% CI, 2.8-7.7; P < 0.001 for subjects aged >85 years old), female gender (OR, 1.7; 95% CI, 1.2-2.4; P = 0.005) and plasma L/Z level (OR, 1.2; 95% CI, 1.0-1.5; P = 0.039), and negatively associated with lipid-lowering drugs use (OR, 0.5; 95% CI, 0.3-0.9; P = 0.014 for statin medications) and SFCT (OR, 0.8; 95% CI, 0.7-0.9; P = 0.002).

Conclusions : The prevalence of SDD was high in subjects older than 75 years old. We reported demographic, clinical and biological factors associated with SDD.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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