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Rinat Zainullin, Mukharram Bikbov, Timur Gilmanshin, Gyulli Kazakbaeva, Ellina Rakhimova, Kamilla Safiullina, Songhomitra Panda-Jonas, Iulia Rusakova, Natalia Bolshakova, Guzel Bikbova, Jost B Jonas; Prevalence and associated factors of age-related macular degeneration in a Russian Population. The Ural Eye and Medical Study. Invest. Ophthalmol. Vis. Sci. 2019;60(9):70. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To assess the prevalence and associated factors of age-related macular degeneration (AMD) in a Russian population.
The Ural Eye and Medical Study (UEMS) is a population-based study performed in the city of Ufa/Russia and in villages in a distance of 65 km from Ufa. The inclusion criterion was an age of 40+ years. AMD was diagnosed on fundus photographs and on spectral-domain optical coherence tomograms.
Out of a population of 7328 eligible individuals, 5899 individuals (2580 (43.7%) men) (participation rate:80.5%) participated (mean age:59.0±10.7 years (range:40-94 years)). Assessable fundus photographs were available for 4932 (83.6%) particpants with a mean age of 58.5±10.5 years (range:40.94 years). AMD was detected in 550/4932 individuals or 11.2% (95% confidence interval (CI): 10.3,12.0)., with a prevalence of early, intermediate and late AMD of 8.2% (95%CI:7.4,9.0), 2.4% (95%CI:2.0,2.9), and 0.8% (95%CI:0.5, 1.0), respectively. A higher AMD prevalence was associated with older age (P<0.001; odds ratio (OR): 1.08;95%CI:1.07,1.09), rural region of habitation (P<0.001;OR:1.87;95%CI:1.52,2.29), shorter axial length (P=0.003;OR:0.87;95%CI:0.79, 0.96), and lower prevalence of diabetes mellitus (P=0.001;OR:0.58;95%CI:0.42,0.81). In that model, the AMD prevalence was not significantly associated with gender (P=0.94), or diastolic (P=0.96) or systolic (P=0.98) blood pressure.
In this typical, ethnically mixed, urban and rural Russian population aged 40+ years, the AMD prevalence was 11.2% (95%CI: 10.3,12.0) with the main associated factors of older age, rural region of habitation, shorter axial length and lower prevalence of diabetes mellitus.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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