July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Phenotype of innate immune cells in uveitis associated with axial spondyloarthritis- versus juvenile idiopathic arthritis- associated uveitis
Author Affiliations & Notes
  • Maren Kasper
    Department of Ophthalmology and Ophtha-Lab at St. Franziskus Hospital, Münster, Germany
    Department of Ophthalmology, University Hospital Essen, Essen, Germany
  • Karoline Walscheid
    Department of Ophthalmology and Ophtha-Lab at St. Franziskus Hospital, Münster, Germany
    Department of Ophthalmology, University Hospital Essen, Essen, Germany
  • Björn Laffer
    Department of Ophthalmology and Ophtha-Lab at St. Franziskus Hospital, Münster, Germany
  • Dirk Bauer
    Department of Ophthalmology and Ophtha-Lab at St. Franziskus Hospital, Münster, Germany
  • Martin Busch
    Department of Ophthalmology and Ophtha-Lab at St. Franziskus Hospital, Münster, Germany
  • Karin Loser
    Department of Dermatology - Experimental Dermatology and Immunobiology of the Skin, University Münster, Münster, Germany
  • Thomas Vogl
    Institute of Immunology, University of Münster, Münster, Germany
  • Thomas Langmann
    Experimental Immunology of the Department of Ophthalmology, University of Cologne, Cologne, Germany
  • Gerd Ganser
    Department of Pediatric Rheumatology, St. Josef Stift, Germany
  • Thomas Rath
    Department of Nephrology, Immunology and Osteology, St. Franziskus Hospital, Münster, Germany
  • Arnd Heiligenhaus
    Department of Ophthalmology and Ophtha-Lab at St. Franziskus Hospital, Münster, Germany
    University of Duisburg-Essen, Essen, Germany
  • Footnotes
    Commercial Relationships   Maren Kasper, None; Karoline Walscheid, None; Björn Laffer, None; Dirk Bauer, None; Martin Busch, None; Karin Loser, None; Thomas Vogl, None; Thomas Langmann, None; Gerd Ganser, None; Thomas Rath, None; Arnd Heiligenhaus, None
  • Footnotes
    Support  DFG He 1877/19-1; part of the FOR 2240 program
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 808. doi:
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      Maren Kasper, Karoline Walscheid, Björn Laffer, Dirk Bauer, Martin Busch, Karin Loser, Thomas Vogl, Thomas Langmann, Gerd Ganser, Thomas Rath, Arnd Heiligenhaus; Phenotype of innate immune cells in uveitis associated with axial spondyloarthritis- versus juvenile idiopathic arthritis- associated uveitis. Invest. Ophthalmol. Vis. Sci. 2019;60(9):808.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the systemic immune response involved in anterior uveitis associated with axial spondyloarthritis (SpA), or juvenile idiopathic arthritis (JIA).

Methods : Venous blood samples from healthy controls (n=16) and patients with anterior uveitis, associated with either SpA (n=19) or JIA (n=23), were analyzed. Data were obtained either during active uveitis flare, or after ≥3 months of inactivity. Frequencies of CD56+, MHC-I+, and S100A9+ monocytes, CCR7+ plasmacytoid and monocytic dendritic cells (DC), CD56+dim natural killer (NK) cells and CD3+CD56bright T-cells were analyzed via flow cytometry. Serum S100A8/A9 levels were determined via ELISA.

Results : SpA patients showed a reduced frequency of CD56+dim NK cells during active uveitis, a constitutively activated phenotype of monocytes, and elevated S100A8/A9 serum levels regardless of uveitis or arthritis activity. In contrast, JIA patients showed elevated frequencies of CD56-positive circulating monocytes and activated DC, independent of uveitis or arthritis activity.

Conclusions : While monocytes of JIAU patients appeared to be unmodulated, SpA patients showed features of an activated immune status even during uveitis quiescence, possibly contributing to the clinically typical recurrent course with acute flares of uveitis in SpA patients.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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