Abstract
Presentation Description :
Visual fields and optical coherent tomography (OCT) are routinely obtained in the clinic. However, while visual fields have been used as functional endpoints in clinical trials (e.g., OHTS, EMGT, AGIS, CIGTS, UKGTS), relatively little has been done with OCT, in part because this technology is relatively new. UKGTS is an exception, but even here OCT was a secondary outcome.[1] This presentation explores the ways that OCT, alone and combined with visual fields, might be incorporated into endpoints with the goal of improving the accuracy and time to endpoint detection. We will consider the possible role of: 1. different OCT measures; 2. measures of the function and structure of the macular region; 3. reading centers; and 4. deep learning/AI approaches. In addition, we will explore how previous clinical trials might have benefitted from the addition of OCT endpoints. 1. Garway-Heath et al. Ophthalmology, 2013;120 :68–76.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.