July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Functional (visual fields) and structural (OCT) end points in clinical trials.
Author Affiliations & Notes
  • Donald C Hood
    Psychology and Ophthalmology, Columbia University, New York, New York, United States
  • Footnotes
    Commercial Relationships   Donald Hood, Heidelberg Engr, Inc (F), Heidelberg Engr, Inc (C), Heidelberg Engr, Inc (R), Novartis (C), Topcon, Inc. (F), Topcon, Inc. (C), Topcon, Inc. (R)
  • Footnotes
    Support  NIH Grant EY02115
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 995. doi:
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      Donald C Hood; Functional (visual fields) and structural (OCT) end points in clinical trials.. Invest. Ophthalmol. Vis. Sci. 2019;60(9):995.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Presentation Description : Visual fields and optical coherent tomography (OCT) are routinely obtained in the clinic. However, while visual fields have been used as functional endpoints in clinical trials (e.g., OHTS, EMGT, AGIS, CIGTS, UKGTS), relatively little has been done with OCT, in part because this technology is relatively new. UKGTS is an exception, but even here OCT was a secondary outcome.[1] This presentation explores the ways that OCT, alone and combined with visual fields, might be incorporated into endpoints with the goal of improving the accuracy and time to endpoint detection. We will consider the possible role of: 1. different OCT measures; 2. measures of the function and structure of the macular region; 3. reading centers; and 4. deep learning/AI approaches. In addition, we will explore how previous clinical trials might have benefitted from the addition of OCT endpoints. 1. Garway-Heath et al. Ophthalmology, 2013;120 :68–76.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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