July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Self-delivery siRNA to prevent corneal scarring
Author Affiliations & Notes
  • Audrey M Bernstein
    SUNY Upstate Medical University, Syracuse, New York, United States
  • Footnotes
    Commercial Relationships   Audrey Bernstein, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 1039. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Audrey M Bernstein; Self-delivery siRNA to prevent corneal scarring. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1039.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Presentation Description : Corneal scarring caused by injury or disease is a significant cause of blindness worldwide. Integrins are key regulators of scar formation and fibrotic outcomes in all tissues. An increase in alphaV-containing integrins on the cell surface of myofibroblasts is a major contributor to scarring. Genetic screening of primary corneal myofibroblasts revealed an upregulation of ubiquitin-mediating enzymes that control integrin turn-over. We found that after wounding, upregulation of deubiquitinases (DUBs) shift the balance towards integrin accumulation by removing ubiquitin from alphav-integrins, in turn preventing normal integrin degradation. The presentation will describe the basic science behind integrins as anti-scarring targets and the use of a single topical application of self-delivery siRNA targeting DUBs to prevent scarring in ex vivo and in vivo models.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.