July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Drusen subtypes and choroidal characteristics in Asian eyes with typical neovascular age-related macular degeneration
Author Affiliations & Notes
  • Junwon Lee
    Yonsei University College of Medicine, Seoul, Korea (the Democratic People's Republic of)
  • Suk Ho Byeon
    Yonsei University College of Medicine, Seoul, Korea (the Democratic People's Republic of)
  • Footnotes
    Commercial Relationships   Junwon Lee, None; Suk Ho Byeon, None
  • Footnotes
    Support  This research was supported by grants of the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (grant number: 2017R1A2B4011045) and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number : HI17C1234).
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 1146. doi:
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      Junwon Lee, Suk Ho Byeon; Drusen subtypes and choroidal characteristics in Asian eyes with typical neovascular age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1146.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the prevalence of pachydrusen, soft drusen, and subretinal drusenoid deposits (SDDs) in eyes with different neovascular age-related macular degeneration (nAMD) subtypes, determine the relationship between each drusen type and the choroidal thickness, and analyze the distinct features of each nAMD subtype according to the drusen type.

Methods : Medical records involving 454 eyes from 454 patients with nAMD were retrospectively reviewed. The prevalence of each drusen type and the choroidal thickness and choroidal characteristics were evaluated according to the nAMD subtype.

Results : Pachydrusen were prevalent in the typical nAMD (40.4%) and polypoidal choroidal vasculopathy (PCV) (47.8%) groups and were not detected in the retinal angiomatous proliferation (RAP) group. No significant drusen were detected in 24.3% of typical nAMD, 43.3% of PCV, and 0% of RAP groups. Regardless of the nAMD subtype, pachydrusen, soft drusen, and SDDs were associated with a thick, moderately thick, and thin choroid, respectively. For eyes with typical nAMD, the prevalence of choroidal vascular hyperpermeability and extrafoveal neovascularization was significantly higher in the pachydrusen group than in the other groups. In contrast, the prevalence of type 2 neovascularization was significantly lower in the pachydrusen group than in the SDD group (P < 0.001 for all).

Conclusions : The prevalence of various drusen differed according to the nAMD subtypes, and each drusen type was strongly associated with the choroidal thickness. Typical nAMD showed distinct features according to the accompanying drusen type.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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