July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Progression of Subclinical Choroidal Neovascularization in Age-Related Macular Degeneration
Author Affiliations & Notes
  • Michael Heiferman
    Northwestern University, Chicago, Illinois, United States
  • Amani A Fawzi
    Northwestern University, Chicago, Illinois, United States
  • Footnotes
    Commercial Relationships   Michael Heiferman, None; Amani Fawzi, None
  • Footnotes
    Support  Research to Prevent Blindness, NY (Department of Ophthalmology, Northwestern University) and 1DP3 DK108248 (AAF)
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 1149. doi:
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      Michael Heiferman, Amani A Fawzi; Progression of Subclinical Choroidal Neovascularization in Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1149.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : To study change in area and morphology of subclinical choroidal neovascularization (CNV) and its correlation with progression in age-related macular degeneration (AMD) using optical coherence tomography angiography (OCTA).

Methods : This study included a total of 34 patients with unilateral neovascular AMD who were prospectively evaluated using OCTA to detect subclinical CNV in the other eye. All patients were monitored for progression to exudative AMD. Patients with baseline subclinical CNV were followed with serial OCTA for a minimum of one year (15.2 ± 3.27 months).

Results : Of the 34 eyes studied, five were found to have baseline subclinical CNV, of whom one eye progressed to exudative AMD requiring initiation of anti-VEGF therapy (20%). None of the remaining twenty-nine eyes without baseline subclinical CNV developed exudative AMD. The average surface area of baseline subclinical CNV was 0.131±0.096 mm2 and 0.136±0.104 mm2 at the final follow up OCTA (P = 0.539).

Conclusions : Our incidence of conversion to exudative AMD in eyes with subclinical CNV of 20% is similar to previous reports and suggests the importance of vigilance in these eyes. We found multiple morphologic changes of subclinical CNV over time; however, there was no significant change in surface area, suggesting that other features may be more important at predicting exudative conversion of these lesions.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.


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