Abstract
Purpose :
To evaluate quantitative optical coherence tomography angiography (OCTA) parameters of treatment-naïve quiescent choroidal neovascularizations (CNVs) and remission type 1 CNVs, in age related macular degeneration (AMD) patients.
Methods :
Eyes included in the study were analyzed using fluorescein angiography, indocyanine green angiography, spectral domain optical coherence tomography (SD-OCT) and OCTA.
On the basis of multimodal imaging evaluation, CNVs were divided into two groups: the group of treatment naïve quiescent CNVs and than of remission type 1 CNVs.
Quantitative analysis of highflow networks in the outer retina segmentation of OCTA, including vessel density (VD), fractal dimension (FD) and lacunarity (LAC) was performed.
Statistical models, showing the ability of each OCTA studied parameter in the discrimination between the two CNVs groups, were built.
Results :
Thirty-one eyes of 31 AMD patients, of whom 18 eyes with treatment-naïve quiescent CNV and 13 eyes with remission type 1 CNV, were included in the study.
Mean VD, FD and LAC were statistically different in the two study groups (all p<0.05).
LAC model showed the best discrimination ability, followed by FD model and VD model (area under the curve= 0.81, 0.75, 0,70; respectively)
Conclusions :
Quantitative OCTA features seem to be useful biomarkers of the CNV status. Then, quantitative OCTA analysis could be an alternative or an adjunct to traditional multimodal imaging in the CNV status classification.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.