July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Quantitative optical coherence tomography angiography features of choroidal neovascularizations in age related macular degeneration.
Author Affiliations & Notes
  • Rita Serra
    Università di Cagliari, Cagliari, Italy
    Università di Sassari, Sassari, Italy
  • Florence Coscas
    Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, Creteil, France, France
  • Diogo Cabral
    Instituto de Oftalmologia Dr. Gama Pinto, Lisboa, Portugal, Portugal
  • Gabriel Coscas
    Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, Creteil, France, France
  • Eric H Souied
    Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, Creteil, France, France
  • Footnotes
    Commercial Relationships   Rita Serra, None; Florence Coscas, None; Diogo Cabral, None; Gabriel Coscas, None; Eric Souied, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 1159. doi:
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      Rita Serra, Florence Coscas, Diogo Cabral, Gabriel Coscas, Eric H Souied; Quantitative optical coherence tomography angiography features of choroidal neovascularizations in age related macular degeneration.. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1159.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate quantitative optical coherence tomography angiography (OCTA) parameters of treatment-naïve quiescent choroidal neovascularizations (CNVs) and remission type 1 CNVs, in age related macular degeneration (AMD) patients.

Methods : Eyes included in the study were analyzed using fluorescein angiography, indocyanine green angiography, spectral domain optical coherence tomography (SD-OCT) and OCTA.
On the basis of multimodal imaging evaluation, CNVs were divided into two groups: the group of treatment naïve quiescent CNVs and than of remission type 1 CNVs.
Quantitative analysis of highflow networks in the outer retina segmentation of OCTA, including vessel density (VD), fractal dimension (FD) and lacunarity (LAC) was performed.
Statistical models, showing the ability of each OCTA studied parameter in the discrimination between the two CNVs groups, were built.

Results : Thirty-one eyes of 31 AMD patients, of whom 18 eyes with treatment-naïve quiescent CNV and 13 eyes with remission type 1 CNV, were included in the study.
Mean VD, FD and LAC were statistically different in the two study groups (all p<0.05).
LAC model showed the best discrimination ability, followed by FD model and VD model (area under the curve= 0.81, 0.75, 0,70; respectively)

Conclusions : Quantitative OCTA features seem to be useful biomarkers of the CNV status. Then, quantitative OCTA analysis could be an alternative or an adjunct to traditional multimodal imaging in the CNV status classification.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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