July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
AI-based prediction of cone- and rod-function based on retinal microstructure in geographic atrophy secondary to age-related macular degeneration
Author Affiliations & Notes
  • Maximilian Pfau
    Department of Ophthalmology, University of Bonn, Bonn, Germany
  • Leon Alexander von der Emde
    Department of Ophthalmology, University of Bonn, Bonn, Germany
  • Chantal Dysli
    Department of Ophthalmology, University of Bonn, Bonn, Germany
  • Philipp T. Möller
    Department of Ophthalmology, University of Bonn, Bonn, Germany
  • Sarah Thiele
    Department of Ophthalmology, University of Bonn, Bonn, Germany
  • Moritz Lindner
    Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom
  • Matthias Schmid
    Institute of Medical Biometry, Medical Informatics, and Epidemiology, University of Bonn, Bonn, Germany
  • Steffen Schmitz-Valckenberg
    Department of Ophthalmology, University of Bonn, Bonn, Germany
  • Frank G. Holz
    Department of Ophthalmology, University of Bonn, Bonn, Germany
  • Monika Fleckenstein
    Department of Ophthalmology, University of Bonn, Bonn, Germany
  • Footnotes
    Commercial Relationships   Maximilian Pfau, Carl Zeiss MediTec (F), CenterVue (F), Heidelberg Engineering (F), Novartis (R), Optos (F); Leon von der Emde, Carl Zeiss MediTec (F), CenterVue (F), Heidelberg Engineering (F), Optos (F); Chantal Dysli, Carl Zeiss MediTec (F), CenterVue (F), Heidelberg Engineering (F), Optos (F); Philipp Möller, Carl Zeiss MediTec (F), CenterVue (F), Heidelberg Engineering (F), Optos (F); Sarah Thiele, Bayer (F), Carl Zeiss MediTec (F), CenterVue (F), Heidelberg Engineering (F), Heidelberg Engineering (R), Optos (F); Moritz Lindner, Carl Zeiss MediTec (F), CenterVue (F), Heidelberg Engineering (F), Optos (F); Matthias Schmid, Bayer (C), Galimedix (C); Steffen Schmitz-Valckenberg, Acucela (F), Alcon/Novartis (C), Alcon/Novartis (F), Alcon/Novartis (R), Allergan (F), Allergan (R), Bayer (F), Bayer (R), Bioeq/Formycon (F), Bioeq/Formycon (C), Carl Zeiss Meditec (F), Carl Zeiss Meditec (R), CenterVue (F), Formycon (F), Galimedix (C), Genentech/Roche (F), Genentech/Roche (R), Heidelberg Engineering (F), Katairo (F), Optos (F); Frank Holz, Acucela (C), Acucela (F), Allergan (F), Allergan (R), Appelis (C), Appelis (R), Bayer (C), Bayer (F), Bioeq/Formycon (F), Bioeq/Formycon (C), Boehringer-Ingelheim (C), Carl Zeiss MediTec (F), CenterVue (F), Ellex (R), Geuder (C), Grayburg Vision (C), Heidelberg Engineering (C), LinBioscience (C), NightStarX (F), Novartis (C), Optos (F), Oxurion (C), Pixium Vision (C), Roche/Genentech (C), Stealth BioTherapeutics (C); Monika Fleckenstein, Alcon/Novartis (F), Alcon/Novartis (R), Bayer (F), Bayer (R), Carl Zeiss MedicTec (F), CenterVue (F), German Research Foundation (DFG): FL 658/4-1 and FL 658/4-2 (F), Heidelberg Engineering (F), Heidelberg Engineering (R), Pending patent: US20140303013 A1 (P), Roche (C)
  • Footnotes
    Support  German Research Foundation (DFG): FL 658/4-1 and FL 658/4-2; Novartis Pharma EYEnovative research award
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 1179. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Maximilian Pfau, Leon Alexander von der Emde, Chantal Dysli, Philipp T. Möller, Sarah Thiele, Moritz Lindner, Matthias Schmid, Steffen Schmitz-Valckenberg, Frank G. Holz, Monika Fleckenstein; AI-based prediction of cone- and rod-function based on retinal microstructure in geographic atrophy secondary to age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1179.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To investigate the association of retinal microstructure with cone- and rod-function in geographic atrophy (GA) secondary to age-related macular degeneration (AMD) using artificial intelligence (AI) algorithms.

Methods : Mesopic, dark-adapted (DA) cyan and red sensitivity were measured using fundus-controlled perimetry (“microperimetry”). Test-points were placed along "iso-hulls" at pre-defined distances to the GA boundary using patient-tailored perimetry grids. Retinal microstructure was assessed through spectral-domain optical coherence tomography (SD-OCT) imaging. Fundus-controlled perimetry data were registered to SD-OCT data based on vessel bifurcations. Reflectivity and thickness values were extracted for six retinal layers for each test-point. Using random forest regression, we evaluated (i) the cross-validated (CV) mean absolute error (MAE) with and without patient-specific training data and (ii) increase in out-of-bag mean-squared error (%IncMSE) as measure of SD-OCT feature importance.

Results : Thirty eyes of 30 patients (76.4±7.1 years; 16 female) with GA from the prospective natural progression study DSGA (Directional Spread in Geographic Atrophy; NCT02051998) and 40 normal eyes form 40 age-similar subjects were included. For patients with GA, sensitivity was predicted with a MAE [95% CI] of 4.15 dB [3.39; 4.91] for mesopic, 5.46 dB [4.64; 6.27] for DA cyan and 3.98 dB [3.44; 4.53] for DA red testing in absence of patient-specific data. Partial addition of patient-specific sensitivity data to the training sets decreased the MAE to 2.53 dB [2.49; 2.58], 3.21 dB [3.16; 3.26] and 2.55 dB [2.52; 2.58]. For all three types of testing, the outer nuclear layer thickness constituted the most important feature (70.88, 78.66 and 107.81 %IncMSE). AI-based spatial mapping of “inferred sensitivity” across the whole retina imaged by SD-OCT and comparison to normal data revealed that DA cyan sensitivity loss spatially exceeded mesopic sensitivity loss in eyes with GA.

Conclusions : AI-based “inferred sensitivity” mapping may be applicable as quasi-functional clinical outcome to (partially) substitute for time-consuming psychophysical testing. Rod-function appears to be more severely affected in eyes with GA secondary to AMD and may constitute a potential therapeutic target to prevent downstream cone-degeneration.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×