July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Change in subfoveal choroidal thickness in subjects with outer retinal tubulation secondary to late, non-exudative age related macular degeneration
Author Affiliations & Notes
  • Vanessa Lizarraga
    Doheny Eye Institute, Los Angeles, California, United States
  • Amir H Hariri
    Doheny Eye Institute, Los Angeles, California, United States
  • Muneeswar Gupta Nittala
    Doheny Eye Institute, Los Angeles, California, United States
  • swetha velaga
    Doheny Eye Institute, Los Angeles, California, United States
  • Jianqin Lei
    Doheny Eye Institute, Los Angeles, California, United States
  • Srinivas R Sadda
    Doheny Eye Institute, Los Angeles, California, United States
    Ophthamology, University of California, Los Angeles, Los Angeles, California, United States
  • Michael S Ip
    Doheny Eye Institute, Los Angeles, California, United States
    Ophthamology, University of California, Los Angeles, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Vanessa Lizarraga, None; Amir Hariri, None; Muneeswar Nittala, None; swetha velaga, None; Jianqin Lei, None; Srinivas Sadda, Allergan (C), Amgen (C), Carl Zeiss Meditec (F), Centervue (C), Centervue (F), Genentech/Roche (C), Heidelberg (C), Nidek (F), Novartis (C), Optos (C), Optos (F), Oxurion (C), Topcon (F); Michael Ip, Allergan (C), Astellas Institute for Regenerative Medicine (C), Boehringer Ingelheim (C), Genentech (C), Omeros (C), Quark (C), Thrombogenics (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 1189. doi:
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      Vanessa Lizarraga, Amir H Hariri, Muneeswar Gupta Nittala, swetha velaga, Jianqin Lei, Srinivas R Sadda, Michael S Ip; Change in subfoveal choroidal thickness in subjects with outer retinal tubulation secondary to late, non-exudative age related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1189.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate change in subfoveal choroidal thickness over 2 years in subjects with outer retinal tubulation (ORT) secondary to late, non-exudative age related macular degeneration.

Methods : One hundred and thirty eyes of 130 subjects with geographic atrophy secondary to dry age related macular degeneration were enrolled in this IRB approved retrospective study. Eyes with reticular pseudodrusen were excluded from this analysis. Cirrus 5000 (Carl Zeiss Meditech Inc, Dublin, CA, USA) spectral domain optical coherence tomography (SD-OCT) was used to capture volumes scans (6X6 macular cube with 512 A-scans and 128 B-scans) of the first visit (baseline) and 2 years follow-up. Baseline OCT images were assessed for the presence of outer retinal tubulation (ORT). Subfoveal choroidal thickness (SFCT) was measured in all subjects at baseline and 2 year follow-up using the instrument manufacturers’ calipers tool. Data was analyzed using SPSS 18.0 software and student t-test was performed.

Results : Outer retinal tubulation (ORT) was identified in 24 of 130 eyes. There was no significant difference in SFCT at baseline between eyes with ORT and without ORT. In eyes with ORT, the mean ± SD SFCT at baseline (206 ± 48 µm) was not statistically (p=0.78) different when compared to SFCT at the 2 year follow-up (203 ± 47 µm). Similar results were observed in eyes without ORT—at baseline 185 ± 44 µm and at the 2 year follow up 181 ± 40 µm (p=0.40).

Conclusions : Subfoveal choroidal thickness was not significantly different in eyes with and without ORT, suggesting that, in at least this small cohort of eyes with ORT, subfoveal choroidal thickness is not associated with the presence of ORT in eyes with GA.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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