July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Progression of Outer Retinal Tubulation Volume in Eyes with Geographic Atrophy due to Age-related Macular Degeneration
Author Affiliations & Notes
  • Chris Okonkwo
    Doheny Eye Institute, Los Angeles, California, United States
  • Amir H Hariri
    Doheny Eye Institute, Los Angeles, California, United States
  • Muneeswar Gupta Nittala
    Doheny Eye Institute, Los Angeles, California, United States
  • swetha velaga
    Doheny Eye Institute, Los Angeles, California, United States
  • Jianqin Lei
    Doheny Eye Institute, Los Angeles, California, United States
  • Srinivas R Sadda
    Doheny Eye Institute, Los Angeles, California, United States
    Ophthamology, University of California, Los Angeles, Los Angeles, California, United States
  • Michael S Ip
    Doheny Eye Institute, Los Angeles, California, United States
    Ophthamology, University of California, Los Angeles, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Chris Okonkwo, None; Amir Hariri, None; Muneeswar Nittala, None; swetha velaga, None; Jianqin Lei, None; Srinivas Sadda, Allergan (C), Amgen (C), Carl Zeiss Meditec (F), Centervue (C), Centervue (F), Genentech/Roche (C), Heidelberg (C), Nidek (F), Novartis (C), Optos (C), Optos (F), Oxurion (C), Topcon (F); Michael Ip, Allergan (C), Astellas Institute for Regenerative Medicine (C), Boehringer Ingelheim (C), Genentech (C), Omeros (C), Quark (C), Thrombogenics (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 1190. doi:
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      Chris Okonkwo, Amir H Hariri, Muneeswar Gupta Nittala, swetha velaga, Jianqin Lei, Srinivas R Sadda, Michael S Ip; Progression of Outer Retinal Tubulation Volume in Eyes with Geographic Atrophy due to Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1190.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the change over time in outer retinal tubulation volume in eyes with geographic atrophy secondary to age related macular degeneration.

Methods : One hundred and thirty eyes of 130 subjects with geographic atrophy secondary to non-exudative age related macular degeneration were enrolled in this IRB approved retrospective study. Spectral domain optical coherence tomography (SD-OCT, Zeiss meditech, USA) volumes scans (6X6 macular cube with 512 A-scans and 128 B-scans) of first visit (baseline) and 2 years follow up were collected from the Doheny Eye Institute/UCLA. Baseline OCT images were assessed for the presence of outer retinal tubulation (ORT). SD-OCT scans of the baseline and 2 years visits of the cases that showed ORT at baseline were imported into a custom OCT grading software program (3D-OCTOR). Two independent certified graders manually graded the boundary of the circular cross sections of the tubules, which were seen as hyporeflective spaces with hyperreflective rims. Software then computed the volume of the tubules. Mean ORT volume at baseline and 2 years was compared using a paired t test.

Results : Twenty-four out of 130 eyes demonstrated ORT at both baseline and at 2 years. The total volume of ORT lesions at the baseline and 2 years visits for all 24 cases was 0.039 ± 0.016 mm3 (range, 0.070 – 0.015 mm3) and 0.037 ± 0.013 mm3 (range, 0.060 – 0.020 mm3) respectively. The difference between these two volumes was not statistically significant (p=0.58).

Conclusions : In eyes with GA that also had ORT at baseline, the volume of the tubules did not change over time. This suggests that eyes with GA and ORT at baseline, the ORT are likely end-stage and further progression of ORT volume is unlikely. This has therapeutic implications, and suggests that the measurement of ORT volume may not be a viable biomarker for progression of disease.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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