Abstract
Purpose :
Sumoylation plays an important role iin regulating lens differentiation (Gong et al., 2014. PNAS). Here, we determined the differential expression patterns of the de-sumoylation enzymes, SENP1 to SENP8 in different ocular tissues and major ocular disease models for cataract and age-related macular degeneration (AMD).
Methods :
QRT-PCR, and Western blot analysis were used for analyzing the expression patterns of de-sumoylation enzymes SENP1 to SENP8.
Results :
Desumoylation enzymes SENP1 to SENP8 are differentially expressed in retina, lens and cornea. In animal models with major ocular diseases, the expression patterns of these enzymes are significantly changed.
Conclusions :
Sumoylation plays an essential role in ocular physiology, and it is also implicated in cataractogenesis and AMD development [Supported by the grant (No. 81570824) from the National Natural Science Foundation of China, and the Fundamental Funds of the State Key Laboratory of Ophthalmology of Zhongshan Ophthalmic Center in Sun Yat-sen University].
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.