July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Generation of mammalian Near-infrared vision by Upconversion nanoparticles
Author Affiliations & Notes
  • Jin Bao
    School of Life Science, University of Science and Technology of China, Hefei, China
  • Yuqian Ma
    School of Life Science, University of Science and Technology of China, Hefei, China
  • Gang Han
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States
  • Tian Xue
    School of Life Science, University of Science and Technology of China, Hefei, China
  • Footnotes
    Commercial Relationships   Jin Bao, None; Yuqian Ma, None; Gang Han, None; Tian Xue, None
  • Footnotes
    Support  National Natural Science Foundation of China 81790644
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 1311. doi:
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      Jin Bao, Yuqian Ma, Gang Han, Tian Xue; Generation of mammalian Near-infrared vision by Upconversion nanoparticles. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1311.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The upper limit of our mammalian visual spectrum is dictated by the physical thermodynamic property of opsin, the photon detecting protein. The so-called visible light is light of wavelength from 400-700 nm. The ability to detect light beyound this spetral limit is of great interests in both visual science research and practical applications.

Methods : In order to extend the visible light spectrum, we developed the ocular injectable and photoreceptor-binding upconversion nanoparticles (UCNPs) that can be intimately integrated with the mammalian retinal photoreceptors as miniature self-powered near-infrared (NIR) light transducers to generate mammalian near-infrared (NIR) imaging vision.

Results : We demonstrated mice recieved UCNPs injection obtained NIR light image vision. The UCNPs in the retina did not create inflammation, retinal degeneration and further toxic side effects. Furthermore, we examined the photoresponses, light adaptation and noise characteristics of photoreceptors bearing UCNPs. Our results demonstrated the biocompatibility of the ocular injectable photoreceptor-binding UCNPs.

Conclusions : This new method will provide opportunities for emerging bio-integrated nanodevice designs and applications, as well as for visual science research.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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