July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
PERP-ing the points of contact between ER and plasma membrane: modulation of ER stress and apoptosis in uveal melanoma
Author Affiliations & Notes
  • Luminita I Paraoan
    Eye and Vision Science, University of Liverpool, Liverpool, ENGLAND, United Kingdom
    Institute of Ageing and Chronic Disese, Liverpool, United Kingdom
  • Footnotes
    Commercial Relationships   Luminita Paraoan, None
  • Footnotes
    Support  The Humane Research Trust UK
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 1364. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Luminita I Paraoan; PERP-ing the points of contact between ER and plasma membrane: modulation of ER stress and apoptosis in uveal melanoma. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1364.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Presentation Description : PERP is a plasma membrane (PM)-localised apoptosis effector protein that was identified as a key determinant of tumour aggressiveness and metastasis risk, being significantly downregulated in monosomy 3 uveal melanoma (UM). Its unexpected interaction with the major endoplasmic reticulum (ER) calcium pump SERCA2b was recently identified and validated in UM cells. Significantly, this interaction was shown to occur at points of contact between the ER and PM and increased during both ER stress and SERCA2b-mediated apoptosis. The PERP-SERCA2b complex appears to directly communicate apoptosis signals from the cell surface to the ER, likely via calcium transfer. The findings underpin the firstly described apoptosis mechanism governing apoptosis involving ER-PM points of contact and indicate that PERP-deficient UM tumours lack a functional ER-PM junctional axis for apoptosis induction involving calcium signals.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×