July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
GABAergic ipRGCs in the mouse retina
Author Affiliations & Notes
  • Tiffany M Schmidt
    Neurobiology, Northwestern University, Evanston, Illinois, United States
  • Takuma Sonoda
    Neurobiology, Northwestern University, Evanston, Illinois, United States
  • Footnotes
    Commercial Relationships   Tiffany Schmidt, None; Takuma Sonoda, None
  • Footnotes
    Support  NIH Grant 1DP2EY022584, a Klingenstein-Simons Fellowship in the Neurosciences, and a Sloan Research Fellowship to TMS and T32 EY025202 support for TS
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 1374. doi:
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    • Get Citation

      Tiffany M Schmidt, Takuma Sonoda; GABAergic ipRGCs in the mouse retina. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1374.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The mammalian retina contains three classes of photoreceptors: rods, cones and intrinsically photosensitive retinal ganglion cells (ipRGCs). ipRGCs directly project to over 10 brain areas to mediate a wide range of visual behaviors such as circadian photoentrainment, pupil constriction, and contrast detection. Current evidence points to ipRGCs executing these functions by primarily releasing the excitatory neurotransmitter glutamate and the peptide transmitter pituitary adenylate cyclase-activating peptide (PACAP). The purpose of this study was to determine whether there is a subpopulation of RGCs that is GABAergic and to identify their central targets and whether the functionally release GABA.

Methods : We used mouse genetics, viral circuit tracing, and optogenetics to map the cell types and circuits of GABAergic RGCs.

Results : Here, we report that a small population of ipRGCs are GABAergic. This population of GABAergic ipRGCs project to the suprachiasmatic nucleus (SCN) and the intergeniculate leaflet (IGL), where they functionally release GABA.

Conclusions : These results identify a novel inhibitory circuit mediated by retinal ganglion cells in the mouse visual system.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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