July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Evaluation of Changes in Choroidal Thickness and the Choroidal Vascularity Index after Hemodialysis in Patients with End-Stage Renal Disease by using Swept-Source Optical Coherence Tomography
Author Affiliations & Notes
  • Heeyoon Cho
    Nephrology, Hanyang University College of medicine, Seoul, Korea (the Republic of)
  • Yong Un Shin
    Nephrology, Hanyang University College of medicine, Seoul, Korea (the Republic of)
  • Doo Roo Kim
    Nephrology, Hanyang University College of medicine, Seoul, Korea (the Republic of)
  • sang eun lee
    Nephrology, Hanyang University College of medicine, Seoul, Korea (the Republic of)
  • Joo Hark Yi
    Nephrology, Hanyang University College of medicine, Seoul, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Heeyoon Cho, None; Yong Un Shin, None; Doo Roo Kim, None; sang eun lee, None; Joo Hark Yi, None
  • Footnotes
    Support  NRF-2017R1D1A1B03030905 and NRF-2017R1D1A1B03031934
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 1545. doi:
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      Heeyoon Cho, Yong Un Shin, Doo Roo Kim, sang eun lee, Joo Hark Yi; Evaluation of Changes in Choroidal Thickness and the Choroidal Vascularity Index after Hemodialysis in Patients with End-Stage Renal Disease by using Swept-Source Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1545.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the effect of hemodialysis on choroidal thickness and the choroidal vascularity index in patients with end-stage renal disease by using swept-source optical coherence tomography.

Methods : Thirty-two eyes of 32 patients with end-stage renal disease undergoing hemodialysis were recruited prospectively. Detailed ophthalmologic examinations and swept-source optical coherence tomography were performed immediately before and after hemodialysis. Choroidal thickness maps were generated automatically by using a built-in software. The choroidal vascularity index was calculated using binarized choroidal optical coherence tomography images. Systemic parameters such as body weight and blood pressure were also measured. The changes in systemic and ocular parameters during hemodialysis were evaluated. Subjects were divided into two groups (diabetes mellitus vs. non-diabetes mellitus) for subgroup analysis.

Results : Total choroidal thickness showed a significant overall decrease after hemodialysis (-10.9 ± 14.0, p<0.001). In the subgroup analysis, total choroidal thickness significantly decreased in both patients with diabetes mellitus (-11.3 ± 13.6, p=0.004) and those without (-10.6 ± 14.9, p=0.020), but the reduction of choroidal thickness was observed in more subfields in patients with diabetes mellitus than in those without. The choroidal vascularity index did not significantly change after hemodialysis (p=0.717). No significant systemic and ocular factors affected the changes in total retinal and choroidal thicknesses.

Conclusions : Choroidal thickness significantly decreased after hemodialysis in most subfields regardless of the presence of diabetes mellitus. Peri-hemodialysis choroidal changes could be considered in the management of patients with end-stage renal disease. Swept-source optical coherence tomography can provide ample and reliable quantitative data for monitoring ocular hemodynamic changes.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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