July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Central serous chorioretinopathy: Hypofluorescent areas on late-phase indocyanine angiography are risk factor of serous retinal detachment
Author Affiliations & Notes
  • Ari Shinojima
    Ophthalmology, Lariboisière Hospital, Université Paris 7, Paris, France
  • Elodie Bousquet
    Ophthalmology, Hôpital Hôtel-Dieu Cochin, Ophtalmopôle, Assistance Publique-Hôpitaux de Paris, AP-HP, Université Paris 5, Sorbonne Paris Cité, Paris, France
    INSERM U1138, Team 17, Université Paris Descartes Sorbonne Paris Cité, Centre de Recherche des Cordeliers, Paris, France
  • Alain Gaudric
    Ophthalmology, Lariboisière Hospital, Université Paris 7, Paris, France
  • Chadi Mehanna
    Ophthalmology, Hôpital Hôtel-Dieu Cochin, Ophtalmopôle, Assistance Publique-Hôpitaux de Paris, AP-HP, Université Paris 5, Sorbonne Paris Cité, Paris, France
    Biostatistics, Hôpital Necker-Enfants Malades, AP-HP, Paris, France
  • Carlo Lavia
    Ophthalmology, Lariboisière Hospital, Université Paris 7, Paris, France
  • Ramin Tadayoni
    Ophthalmology, Lariboisière Hospital, Université Paris 7, Paris, France
    Ophthalmology, Hôpital Hôtel-Dieu Cochin, Ophtalmopôle, Assistance Publique-Hôpitaux de Paris, AP-HP, Université Paris 5, Sorbonne Paris Cité, Paris, France
  • Footnotes
    Commercial Relationships   Ari Shinojima, None; Elodie Bousquet, None; Alain Gaudric, None; Chadi Mehanna, None; Carlo Lavia, None; Ramin Tadayoni, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 1586. doi:https://doi.org/
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    • Get Citation

      Ari Shinojima, Elodie Bousquet, Alain Gaudric, Chadi Mehanna, Carlo Lavia, Ramin Tadayoni; Central serous chorioretinopathy: Hypofluorescent areas on late-phase indocyanine angiography are risk factor of serous retinal detachment. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1586. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To describe the prevalence of focal hypo-fluorescent areas (FHFA) on late-phase indocyanine green angiography (ICGA) in fellow eyes of symptomatic central serous chorioretinopathy (CSC) and evaluate their possible association with the development of serous retinal detachment (SRD).

Methods : Consecutive unilateral symptomatic CSC patients were retrospectively analyzed. Inclusion criteria included the availability of a late phase ICGA (over 25 min) and a Spectral Domain OCT macular cube (Spectralis, Heidelberg Engineering, Germany) for both eyes at baseline and over three months. Subsequent fundus imaging of fellow eyes was reviewed for the development of SRD.

Results : Unilateral forty-five symptomatic CSC patients were analyzed with a median follow-up duration of 15 months (range, 3-62). All forty-five patients had FHFA at baseline in symptomatic CSC eye on late-phase ICGA. In the fellow eye, 30 (66.7%) patients had FHFA at baseline. During the follow-up, 10 out of 30 patients with FHFA developed an SRD, while no patient with normal ICGA developed SRD (p=0.01, Log-rank test).

Conclusions : FHFA on late-phase ICGA are present in all symptomatic CSC eyes and over two-thirds of fellow eyes of symptomatic CSC, and their presence may constitute a risk factor for SRD.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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