July 2019
Volume 60, Issue 9
ARVO Annual Meeting Abstract  |   July 2019
Comparison of ultra wide field angiography to the 7 classic fields in the screening, follow-up and classification of proliferative sickle cell retinopathy
Author Affiliations & Notes
  • Gwenola Drouglazet
    Avicenne hospital, Bobigny, France
  • Franck Fajnkuchen
    Avicenne hospital, Bobigny, France
  • Bahram Bodaghi
    Avicenne hospital, Bobigny, France
  • Audrey Giocanti
    Avicenne hospital, Bobigny, France
  • Footnotes
    Commercial Relationships   Gwenola Drouglazet, None; Franck Fajnkuchen, None; Bahram Bodaghi, None; Audrey Giocanti, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 1709. doi:https://doi.org/
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      Gwenola Drouglazet, Franck Fajnkuchen, Bahram Bodaghi, Audrey Giocanti; Comparison of ultra wide field angiography to the 7 classic fields in the screening, follow-up and classification of proliferative sickle cell retinopathy. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1709. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : To date, there is no gold standard exam for the screening, classification and follow-up of sickle cell retinopathy. However, for diabetic retinopathy, the reference is the 7 EDTRS fields photographs. We performed a mono center observational cross-sectional study to compare ultra-wide field angiography to 7 ETDRS fields in patients presenting or screened for sickle cell retinopathy (SCR).

Methods : 59 eyes of 30 patients, who had underwent Ultra-wide-field (UWF) angiography (Optos ©, Optos Inc., Scotland) for screening or follow-up between September 2016 and April 2018, were included. Ultra-wide-field were interpreted and then another analysis was made by superimposing the ETDRS grid (software Optos ©) over the UWF retinography. The stage of SCR was defined for each case using the Goldberg classification.

Results : After UWF images analysis, 96.6% of the eyes assessed had sickle cell retinopathy: 47.5% stage 2, and 49.1% stage 3. 52 eyes (88.1%) showed differences between the UWF and the ETDRS 7 snapshots.
Among these 52 images, 46.2% were qualified as stage 2 sickle cell retinopathy in UWF but normal in the 7 ETDRS fields and 32.7% were qualified as stage 3 in UWF but normal on the 7 ETDRS fields. Thus, 41 out of 59 (69.5%) of the cases had UWF (stage 2 or 3) SCR that was not diagnosed with the 7 ETDRS fields. 24 eyes categorized as "stage 3 retinopathy" in UWF (82.7%) were not diagnosed with ETDRS images.

Conclusions : This study showed the clear superiority of the ultra-wide field imaging technique in the screening and classification of proliferative SCR compared to the 7 ETDRS fields.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.


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