July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Pupil Diameter Difference (PDD) During Accommodation is The Important Factor for Presbyopia.
Author Affiliations & Notes
  • Miyuki Kubota
    Ophthalmology, Keio University, Shinjyuku, Tokyo, Japan
    Ophthalmology, Keiiku Hospital, Fujisawa-city, Kanagawa, Japan
  • Shunsuke Kubota
    Ophthalmology, Keio University, Shinjyuku, Tokyo, Japan
    Ophthalmology, Keiiku Hospital, Fujisawa-city, Kanagawa, Japan
  • Kazuno Negishi
    Ophthalmology, Keio University, Shinjyuku, Tokyo, Japan
  • Kazuo Tsubota
    Ophthalmology, Keio University, Shinjyuku, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Miyuki Kubota, None; Shunsuke Kubota, None; Kazuno Negishi, None; Kazuo Tsubota, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 1801. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Miyuki Kubota, Shunsuke Kubota, Kazuno Negishi, Kazuo Tsubota; Pupil Diameter Difference (PDD) During Accommodation is The Important Factor for Presbyopia.. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1801.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Presbyopia is the loss of accommodation capability that result in the inability to focus on near objects.
Although, aging is the most well-known risk factor for presbyopia, other etiology of presbyopia remains controversial. Presbyopia has large differences among individuals, so that we searched another related factor except for aging.

Methods : Twenty-five healthy volunteers (50 eyes, 9 men and 17 women; mean age 37.4±7.8SD; range 23-48 years) received the measurements of visual acuity, amplitude of accommodation (AA), maximal pupil diameter and minimum pupil diameter under testing AA. AA and pupil size were all measured by ARK-1(NIDEK, Japan). PDD was defined as the difference between maximal pupil diameter and minimum pupil diameter during AA examination. The subjects were divided into two groups of PDD <1.5mm (lower-PDD group) and ≧1.5mm (higher-PDD group). The relationships between these two groups were investigated.

Results : There was a negative correlation between age and AA in all subjects. The lower-PDD group was consisted of 16 subjects, 32 eyes, mean age 38.0±7.17SD. The higher-PDD group was consisted of 9 subjects, 18 eyes, mean age 36.3±8.80SD. Age had no significant differences between these two groups. The lower-PDD group was significantly lower in AA (2.11D±0.33SE) compared to the higher-PDD group (4.26D±0.54SE)(p<0.01). The lower-PDD group had a significant larger minimum pupil size (4.98mm±0.15SE) compared to the higher-PDD group (3.71D±0.26SE)(p<0.01). In addition to age, logMAR, refraction, maximum pupil size had no significant differences between these two groups. Student's t-test was used on this study.

Conclusions : The lower PDD, in oher words, the less amount of pupil miosis showed lower AA with no relation to age. PDD could be another risk factor of presbyopia and a new therapeutic target for presbyopia.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×