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Luminita Tarita-Nistor, Saba Samet, Graham E Trope, Esther G Gonzalez; Intra- and inter-hemispheric travelling wave propagation of rivalry dominance in early glaucoma. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1825.
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Glaucoma is associated with degeneration in the primary visual pathways and in the corpus callosum. We performed a prospective, observational study to evaluate the intra- and inter-hemispheric propagation of the traveling waves of dominance during binocular rivalry. We hypothesized impairments in the dynamics of the travelling waves in early glaucoma.
Twenty patients (mean age 65 ± 12 years) with early stage open angle glaucoma and 25 age-matched controls (mean age 63 ± 10 years) participated. The two groups were matched in functional measures such as stereo-acuity, binocular visual acuity, and visual field mean deviation. Monocular functional and structural measures were equivalent for the left and right eye in each participant. Using Wilson et al.’s travelling waves paradigm (Nature, 2001;412:907-10), the intra- and inter-hemispheric failure rates of traveling waves initiation of rivalry dominance as well as the travelling waves propagation times were recorded for the two groups.
Failure rates and propagation times were analyzed separately with a 2 (Conditions: intra-, inter-) x 2 (Group: control, glaucoma) mixed factorial ANOVA. For failure rates, there was a significant Condition main effect F(1, 43) = 7.9, p = 0.007, partial η2 = 0.16 and a significant Condition x Group interaction effect F(1, 43) = 6.9, p = 0.01, partial η2 = 0.14. Overall, the inter- failure rate was significantly higher than the intra- failure rate, but pairwise comparisons showed that these rates were not different from each other for the glaucoma group; however, the inter- was significantly larger than the intra- failure rates for the control group, p < 0.001. For the propagation times, there was only a significant Condition x Group interaction effect, F(1,36) = 13.7, p = 0.001, partial η2 = 0.28. The propagation time was significantly longer for the inter- than for the intra-hemispheric condition for the control group, p = 0.014, while the opposite was true for the glaucoma group, p = 0.012.
Travelling waves of dominance during binocular rivalry are impaired in both intra- and inter- hemispheric conditions in patients with early glaucoma. These results suggest changes in the visual pathways that can be detected before standard functional measures show deficits.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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