July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Choroidal structural changes in patients with Birdshot Chorioretinopathy
Author Affiliations & Notes
  • Elodie Bousquet
    Ophthalmology, Ophtalmopôle, Hôpital Cochin, Paris, France
    Centre de Recherche des Cordeliers, INSERM U1138, Team 17, Université Paris Descartes Sorbonne Paris Cité, Paris, France
  • Sawsen Salah
    Ophthalmology, Ophtalmopôle, Hôpital Cochin, Paris, France
  • Antoine Brézin
    Ophthalmology, Ophtalmopôle, Hôpital Cochin, Paris, France
  • Dominique Monnet
    Ophthalmology, Ophtalmopôle, Hôpital Cochin, Paris, France
  • Neha Khandelwa
    Tan Tock Seng Hospital, National Healthcare Group Eye Institute, Singapore, Singapore
  • Rupesh Vijay Agrawal
    Tan Tock Seng Hospital, National Healthcare Group Eye Institute, Singapore, Singapore
  • Footnotes
    Commercial Relationships   Elodie Bousquet, None; Sawsen Salah, None; Antoine Brézin, None; Dominique Monnet, None; Neha Khandelwa, None; Rupesh Agrawal, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 1841. doi:
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      Elodie Bousquet, Sawsen Salah, Antoine Brézin, Dominique Monnet, Neha Khandelwa, Rupesh Vijay Agrawal; Choroidal structural changes in patients with Birdshot Chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1841.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To assess choroidal changes in patients with birdshot chorioretinopathy (BSCR) by measuring the Choroidal Vascularity Index (CVI).

Methods : This is a cross-sectional observational study. Patients with BSCR and healthy controls were imaged with enhanced depth imaging (EDI) OCT. The subfoveal choroidal area was segmented into the luminar area (LA) and stromal area. The CVI was defined as the ratio of LA to the total subfoveal choroidal area. For the purpose of the study, intraocular inflammation was defined by the presence of macular edema and/or ≥ 1 + of vitritis and/or vasculitis and/or papillitis.

Results : Eighty BSCR patients (155 eyes) and 22 (44 eyes) healthy controls were included in the study. Sub-foveal choroidal thickness (CT) was lower in the BSCR group compared with the control group (240.1 ± 97.6 vs 303.6 ± 78; p<0.001). CVI was not different between two groups (CVI mean: 67.5% in both groups). Sub-foveal CT was significantly higher in BSCR patients with signs of inflammatory activity compared with the inactive BSCR patients. Using multivariate linear regression model, longer disease duration was associated with lower CVI (p=0.024) whereas the presence of papillitis and thicker central macular thickness were associated with a higher CVI (p=0.007 and p=0.032 respectively).

Conclusions : CVI may be a potential non-invasive tool for monitoring inflammatory activity in BSCR. Further longitudinal studies are warranted to corroborate the application of this index in clinical practice.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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