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Tatsuaki Amari, Ryo Obata, Asahi Fujita, Takahiro Minami, Motoshi Yamamoto, asako ogawa, Daisuke Santo, Nobuyori Aoki, Masahiro Yamanari, Satoshi Sugiyama, Susumu Oshima, keiko azuma, Megumi Honjo, Toshikatsu Kaburaki, Makoto Aihara, Satoshi Kato; Racial difference in RPE and choroid assessed by polarization-sensitive OCT. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1845.
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© ARVO (1962-2015); The Authors (2016-present)
Racial difference in the melanin distribution at the fundus was reported in histological studies, but that is difficult to assess in the living eye. Polarization-sensitive optical coherence tomography (PS-OCT) can measure depolarization that is thought to be associated with melanin. We investigated racial difference in the retinal pigment epithelium (RPE) and the choroid using PS-OCT.
Among patients who visited University of Tokyo Hospital, 27 eyes of 27 Japanese and 7 eyes of 7 Caucasians without any abnormal findings were included. Volumetric dataset of PS-OCT signal intensity and entropy (depolarization characteristics) was automatically segmented into the RPE or the choroidal layer. ETDRS grid (1, 3, and 6 mm diameter) was overlaid and the mean value in each sector (center, inner ring, and outer ring) was calculated.
The average signal intensity or entropy of RPE in Japanese and Caucasian was similar. In choroid, however, signal intensity [dB] was similar (50 vs 51, 50 vs 52, 51 vs 52) while entropy was significantly higher in Japanese than Caucasians in all sectors (0.20 vs 0.07, 0.20 vs 0.07, 0.20 vs 0.07, p<0.001).
This results that melanin content was almost equal in RPE but in choroid it was significantly higher in Japanese was comparable to previous reports using donor eyes. PS-OCT might be helpful to noninvasively evaluate melanin in the fundus.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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