July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Racial difference in RPE and choroid assessed by polarization-sensitive OCT
Author Affiliations & Notes
  • Tatsuaki Amari
    ophthalmology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
  • Ryo Obata
    ophthalmology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
  • Asahi Fujita
    ophthalmology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
  • Takahiro Minami
    ophthalmology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
  • Motoshi Yamamoto
    ophthalmology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
  • asako ogawa
    ophthalmology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
  • Daisuke Santo
    Tomey, Japan
  • Nobuyori Aoki
    Tomey, Japan
  • Masahiro Yamanari
    Tomey, Japan
  • Satoshi Sugiyama
    Tomey, Japan
  • Susumu Oshima
    Tomey, Japan
  • keiko azuma
    ophthalmology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
  • Megumi Honjo
    ophthalmology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
  • Toshikatsu Kaburaki
    ophthalmology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
  • Makoto Aihara
    ophthalmology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
  • Satoshi Kato
    ophthalmology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Tatsuaki Amari, Tomey corporation (F); Ryo Obata, Alcon Pharma (R), Bayer Yakuhin (R), Novartis Pharma K.K. (R), Santen (R), Tomey corporation (F); Asahi Fujita, Tomey corporation (F); Takahiro Minami, QD Laser (F), Seed (F), Tomey corporation (F); Motoshi Yamamoto, Tomey corporation (R); asako ogawa, Tomey corporation (F); Daisuke Santo, Tomey corporation (E); Nobuyori Aoki, Tomey corporation (E), Tomey corporation (P); Masahiro Yamanari, Tomey corporation (E), Tomey corporation (P); Satoshi Sugiyama, tomey coprporation (E), Tomey corporation (P); Susumu Oshima, Tomey corporation (E); keiko azuma, None; Megumi Honjo, None; Toshikatsu Kaburaki, Abbvie (R), Alcon Pharma (F), Alcon Pharma (R), eisai (F), eisai (R), Kowa (R), Mitsubishi tanabe (R), Novartis Pharma (F), Pfizer (R), santen (R), Santen (F), senju (R), Senju (F), Wakamoto (R); Makoto Aihara, Alcon Pharma (F), Alcon Pharma (C), AMO (F), Claukos Japan (C), Crewt (F), Glaukos Japan (F), HOYA (C), innfocus Inc (C), IRIDEX corporation (C), Kowa (F), NItten (F), Novartis Pharma (F), Ono (C), Ono (F), Otsuka (F), Otsuka (C), Pfizer (F), Santen (F), Santen (C), Sato (F), Senju (F), Senju (C), Tomey corporation (F), Wakamoto (F), Wakamoto (C); Satoshi Kato, Alcon Japan (F), Alcon Japan (R), Alcon Pharma (F), Alcon Pharma (R), Bayer Yakuhin (R), HOYA (R), Kowa (R), Mebix (R), Mitsubisi Tanabe (R), Nidek (F), Santen (F), Santen (R), Sanwa (R), Senju (R)
  • Footnotes
    Support  JP18he1302011
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 1845. doi:
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    • Get Citation

      Tatsuaki Amari, Ryo Obata, Asahi Fujita, Takahiro Minami, Motoshi Yamamoto, asako ogawa, Daisuke Santo, Nobuyori Aoki, Masahiro Yamanari, Satoshi Sugiyama, Susumu Oshima, keiko azuma, Megumi Honjo, Toshikatsu Kaburaki, Makoto Aihara, Satoshi Kato; Racial difference in RPE and choroid assessed by polarization-sensitive OCT. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1845.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Racial difference in the melanin distribution at the fundus was reported in histological studies, but that is difficult to assess in the living eye. Polarization-sensitive optical coherence tomography (PS-OCT) can measure depolarization that is thought to be associated with melanin. We investigated racial difference in the retinal pigment epithelium (RPE) and the choroid using PS-OCT.

Methods : Among patients who visited University of Tokyo Hospital, 27 eyes of 27 Japanese and 7 eyes of 7 Caucasians without any abnormal findings were included. Volumetric dataset of PS-OCT signal intensity and entropy (depolarization characteristics) was automatically segmented into the RPE or the choroidal layer. ETDRS grid (1, 3, and 6 mm diameter) was overlaid and the mean value in each sector (center, inner ring, and outer ring) was calculated.

Results : The average signal intensity or entropy of RPE in Japanese and Caucasian was similar. In choroid, however, signal intensity [dB] was similar (50 vs 51, 50 vs 52, 51 vs 52) while entropy was significantly higher in Japanese than Caucasians in all sectors (0.20 vs 0.07, 0.20 vs 0.07, 0.20 vs 0.07, p<0.001).

Conclusions : This results that melanin content was almost equal in RPE but in choroid it was significantly higher in Japanese was comparable to previous reports using donor eyes. PS-OCT might be helpful to noninvasively evaluate melanin in the fundus.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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