July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Biometric comparators in Central Asians with primary angle closure glaucoma (PACG) versus primary angle open glaucoma ( PAOG ).
Author Affiliations & Notes
  • Assel Talaspayeva
    Glaucoma, Kazakh Research institute of eye diseases, Almaty, Kazakhstan
  • Zhibek Zhamanbalina
    Glaucoma, Kazakh Research institute of eye diseases, Almaty, Kazakhstan
  • Albert S Khouri
    Ophtalmology, Rutgers New Jersey Medical School, Newark, New Jersey, United States
  • Footnotes
    Commercial Relationships   Assel Talaspayeva, None; Zhibek Zhamanbalina, None; Albert Khouri, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 1998. doi:https://doi.org/
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      Assel Talaspayeva, Zhibek Zhamanbalina, Albert S Khouri; Biometric comparators in Central Asians with primary angle closure glaucoma (PACG) versus primary angle open glaucoma ( PAOG ).. Invest. Ophthalmol. Vis. Sci. 2019;60(9):1998. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To identify differences of biometrical parameters of the eye in a Central Asian population between patients with PACG vs PAOG.

Methods : Data from Kazakh, Uzbek, Korean, Uyghur, and Kyrgyz (N= 78) with confirmed PACG and (N= 67) with POAG age 45 -69 yr were collected.
Patients were different stages of glaucoma were included. Visual acuity, refraction, IOP (non contact tonometer, Tomey FT -1000), number of glaucoma medications, slit lamp and fundus examination, ultrasound biometry of lens and vitreous (Accutome B-Scan + A-scan Plus 24-6100, Halma), anterior segment (ASOCT ,Visante) were obtained. Anterior chamber parameters were measured.
The optic nerve was measured in all patients with Heidelberg Retina Tomography (confocal scanning laser ophthalmoscopy CSLO;HRT III Heidelberg Engineering). Parameters included area and volume of the disc, disc rim, cup area, and the cup-to-disc ratio.

Results : IOP in Central asian population with PACG averaged 26,4± 0.2 mm with double medication (combined eye drops) vs subjects with POAG 24,7 ± 0.4 mm and 24,6± 0.3 mm and 22,4 ± 0.3 mm with triple drops , respectively. Axial length in patients with PACG averaged 21.9 ± 0.1 mm vs PAOG 23.1 ± 0.3 mm and the thickness of the lens was higher (mean 4.3 ± 0.07 mm) in patients with PACG vs PAOG patients (mean 3.9 ± 0.05 mm) (p <0.05 vs PAOG).
On ASOCT in PACG patients anterior chamber depth averaged 2.12 ± 0,05 mm vs PAOG patients 2.94.0 ± 0,04 mm (p< 0.01). By ASOCT frequency of narrow angles was higher in patients with PACG than in PAOG patients.
HRT Optic disc data is summarized in Table.
Disc area [mm] Cup area [mm] Rim area [mm2] │CDR [cup/disc ratio]
PACG 1.83 1.45 (p <0.01) 0.91 (p <0.01) 0.78 (p <0.01)
PAOG 1.81 0.78 (p =0.12) 1.03 (p =0.11) 0.41 (p =0.09)
The C/D area ratio of the PACG group was greater than that of the PAOG group, (P<0.01).

Conclusions : These findings identified statistically significant differences in Central Asian populations between PACG and POAG in biometric measures. These findings may suggest that patients with PACG who have the predisposing biometrical factors may present with worse disease than those with POAG. All of these factors should be taken into account when caring for central asian patients with PACG and POAG.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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