Abstract
Purpose :
To evaluate and compare the effect and recurrence rate of non-steroidal anti-inflammatory(NSAID) eye drop and steroid eye drop on bacterial corneal ulcer patients response to antibiotics.
Methods :
From Jan. 2017 to Oct. 2018, 40 patients diagnosed with bacterial corneal ulcer were reviewed. 26 patients were treated with steroid eye drop and 14 patients were treated with NSAID eye drop. A retrospective analysis was done. Patients evaluated for the ulcer size, ulcer location, visual acuity, recurrence rate. Anti-inflammatory treatment was started when corneal epithelial defect, corneal infiltration and anterior chamber inflammation were decrease after antibiotic eye drops use. In case of epithelial defect, infiltration, inflammation re-aggravated anti-inflammatory treatment was discontinued.
Results :
There was no significant difference in mean age, sex, ulcer size, ulcer location, and initial visual acuity. All 40 patients developed unilateral bacterial keratitis. In NSAID treated group, 1 of 14 eyes (7.1%) showed re-aggravating inflammation while steroid treated group, 4 of 26 eyes (15.4%) showed re-aggravating inflammation. Recurrence rate was lower in NSAID treated group, however, there was no statistically significant difference between two groups (P=0.452). The best corrected visual acuity before and after treatment was significantly improved in both groups (p <0.001), however, there was no statistically significant difference between two groups (P=0.769).
Conclusions :
In bacterial keratits, NSAID eye drop has similar efficacy on control of inflammation, improvement of visual acuity and advantage on lower recurrence rate in comparison with steroid eye drop treatment.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.