July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Analysis on depth of corneal neovascularization using anterior segment optical coherence tomography angiography in patients following cultivated oral mucosal epithelial sheet transplantation
Author Affiliations & Notes
  • Shoko Kiritoshi
    Ophthalmology, Osaka University Graduate School of Medicine, Suita City, Japan
  • Yoshinori Oie
    Ophthalmology, Osaka University Graduate School of Medicine, Suita City, Japan
  • Kanako Nampei
    Ophthalmology, Osaka University Graduate School of Medicine, Suita City, Japan
  • Misa Morota
    Ophthalmology, Osaka University Graduate School of Medicine, Suita City, Japan
  • Shinnosuke Sato
    Ophthalmology, Osaka University Graduate School of Medicine, Suita City, Japan
  • Reiko Kobayashi
    Ophthalmology, Osaka University Graduate School of Medicine, Suita City, Japan
  • Takeshi Nakao
    Ophthalmology, Osaka University Graduate School of Medicine, Suita City, Japan
  • Takeshi Soma
    Ophthalmology, Osaka University Graduate School of Medicine, Suita City, Japan
  • Shizuka Koh
    Ophthalmology, Osaka University Graduate School of Medicine, Suita City, Japan
  • Kazuichi Maruyama
    Ophthalmology, Osaka University Graduate School of Medicine, Suita City, Japan
  • Satoshi Kawasaki
    Ophthalmology, Osaka University Graduate School of Medicine, Suita City, Japan
  • Motokazu Tsujikawa
    Ophthalmology, Osaka University Graduate School of Medicine, Suita City, Japan
  • Naoyuki Maeda
    Ophthalmology, Osaka University Graduate School of Medicine, Suita City, Japan
  • Kohji Nishida
    Ophthalmology, Osaka University Graduate School of Medicine, Suita City, Japan
  • Footnotes
    Commercial Relationships   Shoko Kiritoshi, None; Yoshinori Oie, None; Kanako Nampei, None; Misa Morota, None; Shinnosuke Sato, None; Reiko Kobayashi, None; Takeshi Nakao, None; Takeshi Soma, None; Shizuka Koh, None; Kazuichi Maruyama, None; Satoshi Kawasaki, None; Motokazu Tsujikawa, None; Naoyuki Maeda, None; Kohji Nishida, Carl Zeiss Meditec (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 2110. doi:
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      Shoko Kiritoshi, Yoshinori Oie, Kanako Nampei, Misa Morota, Shinnosuke Sato, Reiko Kobayashi, Takeshi Nakao, Takeshi Soma, Shizuka Koh, Kazuichi Maruyama, Satoshi Kawasaki, Motokazu Tsujikawa, Naoyuki Maeda, Kohji Nishida; Analysis on depth of corneal neovascularization using anterior segment optical coherence tomography angiography in patients following cultivated oral mucosal epithelial sheet transplantation. Invest. Ophthalmol. Vis. Sci. 2019;60(9):2110.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To analyze depth of corneal neovascularization using anterior segment optical coherence tomography angiography (AS-OCTA) in patients following cultivated oral mucosal epithelial sheet transplantation (COMET).

Methods : Four 3-by-3mm corneal images (upper, lower, nasal, and temporal) were obtained by AS-OCTA from patients following COMET who visited Osaka University Hospital department of Ophthalmology. The depth of corneal neovascularization was evaluated using en-face and B-scan images, and each quadrant image was classified into the following five types: stromal type where neovascularization was detected only in corneal stroma; predominantly stromal type in which neovascularization was observed in both epithelium and stroma, but predominant in stroma; epithelial type in which neovascularization was detected only in epithelium; predominantly epithelial type where neovascularization was located in both layers, and predominant in epithelium; avascular type.

Results : 9 eyes of 7 cases were enrolled. 6 cases were males and 1 case was female. Average age was 61.3 ± 19.1 years. 3 eyes were idiopathic limbal stem cell deficiency, 2 eyes were caused by Stevens Johnson syndrome, 2 eyes by chemical burn, 1 eye by thermal burn, and 1 eye by ocular cicatricial pemphigoid. The total of 36 quadrant images were classified as follows; 4 in stromal types (11.1%), 16 in predominantly stromal type (44.4%), 3 in epithelial type (8.3%), 11 in predominantly epithelial type (30.6%), 2 in avascular type (5.6%). Corneal neovascularization was observed in both epithelium and stroma in 75% of the cases. Most of neovascularization were detected either in epithelium or superficial stroma just beneath the epithelium.

Conclusions : AS-OCTA is a useful tool to evaluate the depth of corneal neovascularization. The analysis has the potential to distinguish conjunctivalization and stromal neovascularization in patients following COMET.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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