Abstract
Presentation Description :
Severe vision loss from geographic atrophy (GA) and advanced dry age-related macular degeneration (AMD) is a major unmet medical need. Cell-based replacement strategies are a potential method of repairing the loss of retinal pigment epithelium (RPE) that is characteristic of GA and also restoring vision or preventing further vision loss. We have performed a phase 1/2a clinical trial of a novel stem cell derived replacement strategy utilizing a monolayer of mature, polarized RPE. In this presentation we will summarize the preclinical and clinical results of this study.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.