July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Seasonal variation of intra-ocular pressure in glaucoma with and without short tear break-up time
Author Affiliations & Notes
  • Masahiko Ayaki
    Keio Univ, Japan
  • Manami Kuze
    Mie Univ, Japan
  • Kenya Yuki
    Keio Univ, Japan
  • motoko kawashima
    Keio Univ, Japan
  • miki uchino
    Keio Univ, Japan
  • Kazuo Tsubota
    Keio Univ, Japan
  • Kazuno Negishi
    Keio Univ, Japan
  • Footnotes
    Commercial Relationships   Masahiko Ayaki, None; Manami Kuze, None; Kenya Yuki, None; motoko kawashima, None; miki uchino, None; Kazuo Tsubota, Alcon (F), Asahi (F), JINS (F), Kao IBC (F), Kowa (F), Mediproduct (F), Meiji (F), Ophtechs INC (F), Otsuka (F), Pizer (F), Plus One INC (F), Rohto Pharma (F), R Tech Ueno (F), Santen (F), Tore INC (F), Toshiba (F), Wakamoto (F), Wakasa Seikatsu (F), White Med (F), Xelox (F); Kazuno Negishi, Fuji Xerox (I), Hitachi (F), Univ View (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 2405. doi:
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      Masahiko Ayaki, Manami Kuze, Kenya Yuki, motoko kawashima, miki uchino, Kazuo Tsubota, Kazuno Negishi; Seasonal variation of intra-ocular pressure in glaucoma with and without short tear break-up time. Invest. Ophthalmol. Vis. Sci. 2019;60(9):2405.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : To evaluate seasonal variation in intra-ocular pressure (IOP) with and without short tear break-up time (SBUT, BUT≤5s) in glaucoma patients.

Methods : This study enrolled 176 consecutive patients, with a mean age of 67.9 years and including 79 males, who visited one of six eye clinics in Japan from Mar 2015 to Feb 2017 for IOP at every season. We compared the seasonal variation in IOP (mean ± SD) across spring (Mar-May), summer (Jun-Aug), fall (Sep-Nov), and winter (Dec-Feb).

Results : IOP (mmHg) in winter and summer was 12.8 ± 3.7/12.8 ± 3.1 for non-glaucoma without SBUT group (n = 47, P = 0.964), 14.8 ± 3.4/13.3 ± 3.4 for non-glaucoma with SBUT group (n = 57, P < 0.001), 14.3 ± 3.2/14.1 ± 3.4 for glaucoma without SBUT group (n = 36, P = 0.489), and 13.3 ± 3.0/11.6 ± 2.9 for glaucoma with SBUT group (n = 36, P < 0.001). Seasonal variation was largest across the seasons in the glaucoma with DED group. The magnitude of seasonal variation was correlated with BUT (β = 0.228, P = 0.003)

Conclusions : Seasonal variation tended to be larger in patients with SBUT than those without SBUT.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.


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