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Masahiko Ayaki, Manami Kuze, Kenya Yuki, motoko kawashima, miki uchino, Kazuo Tsubota, Kazuno Negishi; Seasonal variation of intra-ocular pressure in glaucoma with and without short tear break-up time. Invest. Ophthalmol. Vis. Sci. 2019;60(9):2405.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate seasonal variation in intra-ocular pressure (IOP) with and without short tear break-up time (SBUT, BUT≤5s) in glaucoma patients.
This study enrolled 176 consecutive patients, with a mean age of 67.9 years and including 79 males, who visited one of six eye clinics in Japan from Mar 2015 to Feb 2017 for IOP at every season. We compared the seasonal variation in IOP (mean ± SD) across spring (Mar-May), summer (Jun-Aug), fall (Sep-Nov), and winter (Dec-Feb).
IOP (mmHg) in winter and summer was 12.8 ± 3.7/12.8 ± 3.1 for non-glaucoma without SBUT group (n = 47, P = 0.964), 14.8 ± 3.4/13.3 ± 3.4 for non-glaucoma with SBUT group (n = 57, P < 0.001), 14.3 ± 3.2/14.1 ± 3.4 for glaucoma without SBUT group (n = 36, P = 0.489), and 13.3 ± 3.0/11.6 ± 2.9 for glaucoma with SBUT group (n = 36, P < 0.001). Seasonal variation was largest across the seasons in the glaucoma with DED group. The magnitude of seasonal variation was correlated with BUT (β = 0.228, P = 0.003)
Seasonal variation tended to be larger in patients with SBUT than those without SBUT.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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