July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Effect of General Anesthesia on Intraocular Pressure in Pediatric Patients: A Meta-analysis
Author Affiliations & Notes
  • Sukhumal Thanapaisal
    Ophthalmology, University of California San Francisco, San Francisco, California, United States
    Ophthalmology, Khon Kaen University, Khon Kaen, Thailand
  • Julius Oatts
    Ophthalmology, University of California San Francisco, San Francisco, California, United States
  • Jing Zhao
    Ophthalmology, University of California San Francisco, San Francisco, California, United States
  • Claudio Ignacio Perez
    Ophthalmology, University of California San Francisco, San Francisco, California, United States
  • Qian Liu
    Ophthalmology, University of California San Francisco, San Francisco, California, United States
    Ophthalmology, Henan Eye Institute, Henan, China
  • Travis C Porco
    Ophthalmology, University of California San Francisco, San Francisco, California, United States
  • Ying Han
    Ophthalmology, University of California San Francisco, San Francisco, California, United States
  • Footnotes
    Commercial Relationships   Sukhumal Thanapaisal, None; Julius Oatts, None; Jing Zhao, None; Claudio Perez, None; Qian Liu, None; Travis Porco, None; Ying Han, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 2407. doi:
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    • Get Citation

      Sukhumal Thanapaisal, Julius Oatts, Jing Zhao, Claudio Ignacio Perez, Qian Liu, Travis C Porco, Ying Han; Effect of General Anesthesia on Intraocular Pressure in Pediatric Patients: A Meta-analysis. Invest. Ophthalmol. Vis. Sci. 2019;60(9):2407.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The effect of general anesthesia agents on intraocular pressure in children is still controversial. We performed a meta-analysis to study the change in intraocular pressure (IOP) over time in children following general anesthesia (GA).

Methods : Pubmed, EMBASE, and CENTRAL databases were systematically searched following standard Cochrane guidelines to identify randomized controlled trials, prospective, and interventional studies. IOP, anesthesia time points and different agents during GA were recorded for non-glaucomatous pediatric patients (0-18 years old). The search included all studies through October 5th, 2018 with no date or language restrictions. Data of anesthetic agents use for induction and maintenance phase were extracted, together with IOP at different time points from prior to induction until deep anesthesia phase. Following data extraction, a linear mixed-effects regression analysis was performed.

Results : The search strategy identified 519 studies. Six studies (520 eyes) were included for quantitative synthesis. Seven categories of mixed and non-mixed agents identified by induction and maintenance drugs were compared. By analysis of overall agent, the IOP decreased over time after induction phase at a rate of 0.62 ± 0.095 mmHg/min (mean ± standard error, P-value < 0.001). This is a model of mean IOP as a function of time and agent, weighted by the inverse of variance of each reported outcome and clustered on publications.

Conclusions : This meta-analysis showed that IOP decreases over time following induction of GA in children. Moreover, the model we developed helps ophthalmologists better understand and estimate changes in IOP during GA.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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