July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Decreased macular vessel density measured by optical coherence tomography angiography is associated with a reduced photopic negative response in glaucoma patients
Author Affiliations & Notes
  • Carlo Alberto Cutolo
    Clinica Oculistica, DiNOGMI, Ospedale Policlinico iRCCS San Martino, University of Genova, Genoa, Italy
  • Sergio Claudio Saccà
    Ophthalmic Unit, Ospedale Policlinico San Martino, Genoa, Italy
  • Daniele Ferrari
    Ophthalmic Unit, Ospedale Policlinico San Martino, Genoa, Italy
  • Carlo Enrico Traverso
    Clinica Oculistica, DiNOGMI, Ospedale Policlinico iRCCS San Martino, University of Genova, Genoa, Italy
  • Footnotes
    Commercial Relationships   Carlo Alberto Cutolo, None; Sergio Claudio Saccà, None; Daniele Ferrari, None; Carlo Enrico Traverso, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 2452. doi:
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      Carlo Alberto Cutolo, Sergio Claudio Saccà, Daniele Ferrari, Carlo Enrico Traverso; Decreased macular vessel density measured by optical coherence tomography angiography is associated with a reduced photopic negative response in glaucoma patients. Invest. Ophthalmol. Vis. Sci. 2019;60(9):2452.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the association between the photopic negative response (PhNR) and structural/angiographic optical coherence tomography (OCT) parameters in glaucoma patients.

Methods : This cross-sectional study enrolled patients with primary open angle glaucoma (POAG). All patients completed a full ophthalmological examination. One eye per patients underwent optical biometry, OCT, OCT angiography (OCT-A) and, full-field electroretinography to analyze the PhNR. OCT measurements: ganglion cell layer plus inner plexiform layer thickness (GCL+) and circumpapillary retinal nerve fiber layer (cpRNFL). Macular OCT-A measurements: vascular density of the superficial retinal layer (vd-SRL) and vascular density of the deep retinal layer (vd-DRL). Standard automated perimetry (SAP) was also performed.

Results : The study population consisted of 28 POAG patients. The PhNR significantly correlates with GCL++ thickness and vd-SRL (p=0.02 and p=0.01, respectively) but not with cpRNFL, SAP or, vd-DRL. Multivariate linear regression analysis, while controlling for the potentially confounding effect of age, central corneal thickness (CCT), axial length showed that each 10 μm decrease in GCL+ thickness was associated with a 0.90 μV decrease in the PhNR (p=0.006) and that each 1% decrease in vd-SRL was associated with a 0.35 μV decrease in the PhNR (p<0.001). The multivariate regression also adjusted for the effect of SAP showed that vd-SRL was independently associated with the PhNR (R2=0.677, p<0.001). When controlling for the same variables, GCL+ wasn’t independently associated with the PhNR (p=0.143).

Conclusions : Our study confirms the significant relationship between OCT structural measurements and PhNR. Moreover, we showed a significant association between macular vascular density and the PhNR.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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