July 2019
Volume 60, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2019
Evaluation of fixation loss response to stimulation of physiologic scotoma by Heijl-Krakau method in eyes with the deterioration of sensitivity near the physiologic scotoma.
Author Affiliations & Notes
  • Takuya Ishibashi
    Kindai University Faculty of Medicine, Osakasayama city, OSAKA, Japan
  • Chota Matsumoto
    Kindai University Faculty of Medicine, Osakasayama city, OSAKA, Japan
  • Hiroki Nomoto
    Kindai University Faculty of Medicine, Osakasayama city, OSAKA, Japan
  • Keiji Yoshikawa
    Yoshikawa Eye clinic, Japan
  • Mami Nanno
    Kagurazaka Minamino Eye clinic, Japan
  • Sachiko Okuyama
    Kindai University Faculty of Medicine, Osakasayama city, OSAKA, Japan
  • Fumi Tanabe
    Kindai University Faculty of Medicine, Osakasayama city, OSAKA, Japan
  • Sayaka Yamao
    Kindai University Faculty of Medicine, Osakasayama city, OSAKA, Japan
  • Shinji Kimura
    CREWT Medical, Inc, Japan
  • Shunji Kusaka
    Kindai University Faculty of Medicine, Osakasayama city, OSAKA, Japan
  • Footnotes
    Commercial Relationships   Takuya Ishibashi, None; Chota Matsumoto, None; Hiroki Nomoto, None; Keiji Yoshikawa, None; Mami Nanno, None; Sachiko Okuyama, None; Fumi Tanabe, None; Sayaka Yamao, None; Shinji Kimura, None; Shunji Kusaka, Alcon Japan, Ltd. (F), HOYA Co., Ltd. (F), Johnson & Johnson Surgical Vison, Inc. (F), Kowa Co., Ltd. (F), NIDEK Co., Ltd. (F), Otsuka Pharmaceutical Co., Ltd. (F), RE MEDICAL, Inc. (F), Santen Pharmaceutical Co., Ltd. (F), Senju Pharmaceutical Co.,Ltd. (F), WAKAMOTO Co., Ltd. (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 2459. doi:
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      Takuya Ishibashi, Chota Matsumoto, Hiroki Nomoto, Keiji Yoshikawa, Mami Nanno, Sachiko Okuyama, Fumi Tanabe, Sayaka Yamao, Shinji Kimura, Shunji Kusaka; Evaluation of fixation loss response to stimulation of physiologic scotoma by Heijl-Krakau method in eyes with the deterioration of sensitivity near the physiologic scotoma.. Invest. Ophthalmol. Vis. Sci. 2019;60(9):2459.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Heijl-Krakau method, which evaluates the response to stimulation of physiologic scotoma, has been widely used for evaluating fixation stability of the standard automated perimetry test. While eye movement during visual field test causes inappropriate response to the stimuli of Heijl-Krakau method, there is a possibility that patients who has the deterioration of sensitivity near the physiologic scotoma are less likely to respond to the Heijl-Krakau stimuli, regardless of whether eye movement occurs or not. A newly developed head mounted perimetry imo<span style="font-size:10.8333px">®</span> has an eye tracking system which theoretically enable the device to present the stimuli of the Heijl-Krakau method on optic disc continuously. In this study, we compared the rate of fixation loss (FL) response between eyes with deterioration and no-deterioration of sensitivity near the physiologic scotoma.

Methods : This study enrolled eight hundred eighty-three eyes of 445 glaucoma patients. All eyes were classified into deterioration and no-deterioration groups. Definition of the deterioration group: a sensitivity of (15,-3) test point where the physiologic scotoma corresponded was 0dB and one or more deteriorated test points (< 10dB) in 8 test points around (15,-3) test point. All patients underwent a visual field test with imo<span style="font-size:10.8333px">®</span>. We compared the rate of FL response by Heijl-Krakau method between those 2 groups.

Results : Deterioration group was 163 eyes, and no-deterioration group was 720 eyes. In 163 eyes of deterioration group, 48 eyes showed two or more deteriorated test points. The rate of FL responses were 18.8 ± 22.4% in the no-deterioration group and 11.4 ± 13.6% in the deterioration group. The deterioration group was significantly smaller than the no-deterioration group (p<0.001). The rate of FL response in eyes with two or more deteriorated test points was 10.7 ± 11.7%. In the deterioration group, no significant difference was found between eyes with one deteriorated test point and two or more deteriorated test points.

Conclusions : Our result suggests that Heijl-Krakau method is likely to underestimate FL response when subject has the deterioration of sensitivity near the physiologic scotoma.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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