Abstract
Purpose :
To identify risk factors for fast glaucomatous visual field loss progression in eyes with normotensive preperimetric glaucoma (PPG).
Methods :
We retrospectively investigated 68 eyes, which was initially diagnosed as preperimetric normal tension glaucoma (NTG) and finally converted to manifest glaucoma fulfilling Anderson-Patella’s criteria at the latest three examinations. They had a follow-up period with a minimum of 10 years and more than 10 reliable visual field examinations by standard automated perimetry (HFA program central 30-2). An annual deterioration rate of mean deviation (MD slope) was calculated for each eye. The eyes were assigned into two groups: fast (MD slope ≤ -0.30 dB/year) and slow progressive eyes. Logistic regression model was constructed for statistical analysis.
Results :
The mean age at diagnosis was 51.6 ± 11.2 years. Men were 25, and women 43. The mean follow-up period was 18.9 ± 5.3 years. The MD slope was -0.54 ± 0.15 dB/year in the fast progressive group and -0.09 ± 0.12 dB/year in the slow progressive group. Disc hemorrhages (DHs) were detected 5.1 ± 5.8 times (range: 0 to 18) in the fast progressive group and 2.2 ± 3.0 times (range: 0 to 15) in the slow progressive group (P = 0.011). There was a significant difference in the frequency of DHs (P = 0.012) between the fast and slow progressive groups in multivariate analysis. In addition, no significant difference was identified in any parameters related to intraocular pressure.
Conclusions :
The detection of repeated DHs bears a close relationship to faster glaucomatous visual field loss progression.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.