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Yuki Ido, Yusuke Manabe, Akira Sawada, Tetsuya Yamamoto; Association of repeated disc hemorrhages with faster progression in perimetric normal tension glaucoma. Invest. Ophthalmol. Vis. Sci. 2019;60(9):2469. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To identify risk factors for fast glaucomatous visual field loss progression in eyes with normotensive preperimetric glaucoma (PPG).
We retrospectively investigated 68 eyes, which was initially diagnosed as preperimetric normal tension glaucoma (NTG) and finally converted to manifest glaucoma fulfilling Anderson-Patella’s criteria at the latest three examinations. They had a follow-up period with a minimum of 10 years and more than 10 reliable visual field examinations by standard automated perimetry (HFA program central 30-2). An annual deterioration rate of mean deviation (MD slope) was calculated for each eye. The eyes were assigned into two groups: fast (MD slope ≤ -0.30 dB/year) and slow progressive eyes. Logistic regression model was constructed for statistical analysis.
The mean age at diagnosis was 51.6 ± 11.2 years. Men were 25, and women 43. The mean follow-up period was 18.9 ± 5.3 years. The MD slope was -0.54 ± 0.15 dB/year in the fast progressive group and -0.09 ± 0.12 dB/year in the slow progressive group. Disc hemorrhages (DHs) were detected 5.1 ± 5.8 times (range: 0 to 18) in the fast progressive group and 2.2 ± 3.0 times (range: 0 to 15) in the slow progressive group (P = 0.011). There was a significant difference in the frequency of DHs (P = 0.012) between the fast and slow progressive groups in multivariate analysis. In addition, no significant difference was identified in any parameters related to intraocular pressure.
The detection of repeated DHs bears a close relationship to faster glaucomatous visual field loss progression.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.
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