July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Association of repeated disc hemorrhages with faster progression in perimetric normal tension glaucoma
Author Affiliations & Notes
  • Yuki Ido
    Ophthalmology, Gifu University Graduate School of Medicine, Gifu, Japan, Gifu, Gifu, Japan
  • Yusuke Manabe
    Ophthalmology, Gifu University Graduate School of Medicine, Gifu, Japan, Gifu, Gifu, Japan
  • Akira Sawada
    Ophthalmology, Gifu University Graduate School of Medicine, Gifu, Japan, Gifu, Gifu, Japan
  • Tetsuya Yamamoto
    Ophthalmology, Gifu University Graduate School of Medicine, Gifu, Japan, Gifu, Gifu, Japan
  • Footnotes
    Commercial Relationships   Yuki Ido, None; Yusuke Manabe, None; Akira Sawada, None; Tetsuya Yamamoto, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 2469. doi:https://doi.org/
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      Yuki Ido, Yusuke Manabe, Akira Sawada, Tetsuya Yamamoto; Association of repeated disc hemorrhages with faster progression in perimetric normal tension glaucoma. Invest. Ophthalmol. Vis. Sci. 2019;60(9):2469. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To identify risk factors for fast glaucomatous visual field loss progression in eyes with normotensive preperimetric glaucoma (PPG).

Methods : We retrospectively investigated 68 eyes, which was initially diagnosed as preperimetric normal tension glaucoma (NTG) and finally converted to manifest glaucoma fulfilling Anderson-Patella’s criteria at the latest three examinations. They had a follow-up period with a minimum of 10 years and more than 10 reliable visual field examinations by standard automated perimetry (HFA program central 30-2). An annual deterioration rate of mean deviation (MD slope) was calculated for each eye. The eyes were assigned into two groups: fast (MD slope ≤ -0.30 dB/year) and slow progressive eyes. Logistic regression model was constructed for statistical analysis.

Results : The mean age at diagnosis was 51.6 ± 11.2 years. Men were 25, and women 43. The mean follow-up period was 18.9 ± 5.3 years. The MD slope was -0.54 ± 0.15 dB/year in the fast progressive group and -0.09 ± 0.12 dB/year in the slow progressive group. Disc hemorrhages (DHs) were detected 5.1 ± 5.8 times (range: 0 to 18) in the fast progressive group and 2.2 ± 3.0 times (range: 0 to 15) in the slow progressive group (P = 0.011). There was a significant difference in the frequency of DHs (P = 0.012) between the fast and slow progressive groups in multivariate analysis. In addition, no significant difference was identified in any parameters related to intraocular pressure.

Conclusions : The detection of repeated DHs bears a close relationship to faster glaucomatous visual field loss progression.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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