Abstract
Purpose :
The purpose of this study was to evaluate the non-inferiority of the mean defect when using the new Sequentially Optimized Reconstruction Strategy (SORS) visual field (VF) locations compared to the 30-degree Octopus G1 program (Dynamic strategy) VF locations in healthy and glaucoma subjects.
Methods :
This was a prospective, non-randomized single-center study examining 29 eyes of 29 healthy subjects with normal visual field and 72 eyes of 72 glaucoma subjects with early to moderate visual field loss (mean defect: +2 to +12 dB) with standard automated perimetry. One randomly selected eye of each subject underwent VF assessment with the SORS and Octopus G1 program (Dynamic strategy, DS), in random order. The primary outcome measure was the non-inferiority of the mean defect (MD) in SORS compared to DS. Secondary outcome measures comprised the comparison of test duration, number of test locations and number of stimuli presentations as a function of the testing method and analysis of estimated MD as a function of age and visual acuity. Correlation analysis was done by calculating R squared to determine the regression predictions of SORS. Equivalence testing was performed with the two one-sided t-tests (TOST) for MD values of SORS and DS in healthy and glaucoma subjects, separately.
Results :
The mean defect from SORS and DS showed a moderate to good correlation for 20 and 36 SORS test locations (R2 = 0.4 – 0.5) in healthy and glaucoma subjects, respectively. In healthy subjects the mean MD difference between SORS and DS (59 test locations) was 1.1 dB and 1.2 dB for 36 and 20 SORS test locations, respectively. In subjects with glaucomatous visual field defects the mean MD difference was 1.7 dB and 1.8 dB for 36 and 20 SORS test locations, respectively. Equivalence testing for a MD difference interval of ± 2 dB revealed a significant TOST (P<0.05) for 20 and 36 SORS test locations.
Conclusions :
The new Sequentially Optimized Reconstruction Strategy (SORS) showed a good MD agreement with standard automated perimetry. However, SORS needed only one- or two third of the test locations and therefore significantly reduced the test duration in visual field testing.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.