July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Correlation of the changes of macular capillary network and recurrence of macular edema in branch retinal vein occlusion analyzed with optical coherence tomography angiography
Author Affiliations & Notes
  • Ji-Hye Jang
    Ophthalmology, Keimyung University School of Medicine, Dongsan Medical Center, Daegu, Korea (the Republic of)
  • Kwang-Soo Kim
    Ophthalmology, Keimyung University School of Medicine, Dongsan Medical Center, Daegu, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Ji-Hye Jang, None; Kwang-Soo Kim, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 2556. doi:
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      Ji-Hye Jang, Kwang-Soo Kim; Correlation of the changes of macular capillary network and recurrence of macular edema in branch retinal vein occlusion analyzed with optical coherence tomography angiography. Invest. Ophthalmol. Vis. Sci. 2019;60(9):2556.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate correlation of the morphologic changes of perifoveal capillary network and the recurrence of macular edema (ME) in branch retinal vein occlusion (BRVO) using the swept-source optical coherence tomography (SS-OCT) angiography.

Methods : We retrospectively reviewed the fundus photography, SS-OCT, SS-OCT angiography images of 43 patients who diagnosed treatment näive ME associated with BRVO who treated with intravitreal anti-vascular endothelial growth factor injection. The foveal avascular zone (FAZ) and central vascular density (VD) were analyzed with SS-OCT angiography after resolution of ME. Patients were divided into 2 groups according to the recurrence of ME within 6 months of completely macular edema resolution, and then assessed a relationship between the OCT angiography parameters and the ME recurrence.

Results : In 21 eyes without ME recurrence, the mean superficial FAZ areas in en face 3 × 3 mm SS-OCT angiography image were 0.40 ± 0.11 mm2, the mean deep FAZ areas were 0.48 ± 0.12 mm2. In 22 eyes with ME recurrence, the mean FAZ areas of the superficial capillary plexus (SCP) and the deep capillary plexus (DCP) were 0.52 ± 0.26 mm2, 0.60 ± 0.26 mm2, respectively. Mean FAZ in the SCP and the DCP areas was wider in eyes with ME recurrence group, but, there was a significant differences of the mean FAZ areas in the SCP (p=0.035), rather than in the DCP (p=0.063). The VD at the central 3 × 3 mm area in the SCP & DCP showed no significant differences between two groups (p=0.298, p=0.190). However, in the ME recurrence group, a presence of the perifoveal capillary ring loss in the SCP and the DCP was more common (p=0.047, p=0.002), and a disruption of the perifoveal capillary ring of the DCP (30.0° vs 87.3°, p=0.001) was more severe than that of the SCP (17.3° vs 69.5°, p=0.006).

Conclusions : A destructed foveal capillary ring was related to the recurrence of ME in BRVO. Our study suggested that the greater the destruction of the foveal capillary networks, especially in the deep capillary ring loss, the higher the risk of recurrence of the ME after resolution the ME with BRVO.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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