July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
OPTICAL COHERENCE TOMOGRAPHY PREDICTORS OF SHORT-TERM VISUAL ACUITY IN EYES WITH MACULAR EDEMA SECONDARY TO RETINAL VEIN OCCLUSION TREATED WITH INTRAVITREAL CONBERCEPT
Author Affiliations & Notes
  • Xiang Ma
    Ophthalmology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China
  • Fusheng Tang
    Ophthalmology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China
  • Xiuhong Qin
    Ophthalmology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China
  • Jianmin Lu
    Ophthalmology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China
  • Peng Song
    Ophthalmology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China
  • Mingshu Li
    Ophthalmology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China
  • Footnotes
    Commercial Relationships   Xiang Ma, None; Fusheng Tang, None; Xiuhong Qin, None; Jianmin Lu, None; Peng Song, None; Mingshu Li, None
  • Footnotes
    Support  no grants or support
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 2581. doi:
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      Xiang Ma, Fusheng Tang, Xiuhong Qin, Jianmin Lu, Peng Song, Mingshu Li; OPTICAL COHERENCE TOMOGRAPHY PREDICTORS OF SHORT-TERM VISUAL ACUITY IN EYES WITH MACULAR EDEMA SECONDARY TO RETINAL VEIN OCCLUSION TREATED WITH INTRAVITREAL CONBERCEPT. Invest. Ophthalmol. Vis. Sci. 2019;60(9):2581.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To identify the spectral-domain optical coherence tomography (SD-OCT) predictors of visual prognosis in retinal vein occlusion macular edema (RVO-ME) after intravitreal conbercept injection.

Methods : Retrospective cohort study of 63 treatment-naïve RVO-ME eyes received PRN intravitreal conbercept with at least three months of follow-up. The best-corrected visual acuity(BCVA) and OCT scans were recorded at baseline, one and three months after starting therapy. On SD-OCT, the following lesions in the 1-mm-wide retinal area centered on the fovea:disorganization of the retinal inner layers extent, cysts, hyperreflective foci (HF), microaneurysms,external limiting membrane (ELM) or ellipsoid zone (EZ) disruption, foveal bulge and foveal depression were evaluated by masked graders. Regression analysis was used to determine independent predictors of BCVA at one and three months follow-up.

Results : The thicker central subfield thickness (CST), greater extent of ELM disruption and presence of HF > 20 at baseline correlated with the worse baseline BCVA (all P < 0.05). The greater extent of ELM disruption and presence of HF > 20 at baseline were associated with poorer BCVA during follow-up (all P < 0.05). The CST and extent of EZ disruption at baseline and their changes over time were correlated with the three-month BCVA improvement (all P < 0.05).Furthermore, changes in the EZ disruption extent or CST following one month identified eyes with a high likelihood of subsequent BCVA improvement or decline.

Conclusions : The ELM status and HF > 20 at baseline could be good predictors for short-term visual outcome, while CST and the EZ status at baseline and their changes over time may predict visual improvement in patients with RVO-ME following intravitreal conbercept.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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