Abstract
Purpose :
To identify the spectral-domain optical coherence tomography (SD-OCT) predictors of visual prognosis in retinal vein occlusion macular edema (RVO-ME) after intravitreal conbercept injection.
Methods :
Retrospective cohort study of 63 treatment-naïve RVO-ME eyes received PRN intravitreal conbercept with at least three months of follow-up. The best-corrected visual acuity(BCVA) and OCT scans were recorded at baseline, one and three months after starting therapy. On SD-OCT, the following lesions in the 1-mm-wide retinal area centered on the fovea:disorganization of the retinal inner layers extent, cysts, hyperreflective foci (HF), microaneurysms,external limiting membrane (ELM) or ellipsoid zone (EZ) disruption, foveal bulge and foveal depression were evaluated by masked graders. Regression analysis was used to determine independent predictors of BCVA at one and three months follow-up.
Results :
The thicker central subfield thickness (CST), greater extent of ELM disruption and presence of HF > 20 at baseline correlated with the worse baseline BCVA (all P < 0.05). The greater extent of ELM disruption and presence of HF > 20 at baseline were associated with poorer BCVA during follow-up (all P < 0.05). The CST and extent of EZ disruption at baseline and their changes over time were correlated with the three-month BCVA improvement (all P < 0.05).Furthermore, changes in the EZ disruption extent or CST following one month identified eyes with a high likelihood of subsequent BCVA improvement or decline.
Conclusions :
The ELM status and HF > 20 at baseline could be good predictors for short-term visual outcome, while CST and the EZ status at baseline and their changes over time may predict visual improvement in patients with RVO-ME following intravitreal conbercept.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.