July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Association between retinal vessel analysis and cardiovascular risk profile in Ankylosing Spondylitis patients. Interim analysis of the -An eye for a heart- study.
Author Affiliations & Notes
  • Buket Kinaci- Tas
    Opthalmology, Amsterdam UMC location VUmc, Almere, Netherlands
  • Rianne van Bentum
    Rheumatology, Amsterdam UMC location VUmc, Netherlands
  • Milad Baniaamam
    Rheumatology, Amsterdam UMC location VUmc, Netherlands
  • Aleid van de Kreeke
    Opthalmology, Amsterdam UMC location VUmc, Almere, Netherlands
  • Merve Koçyiğit
    Rheumatology, Amsterdam UMC location VUmc, Netherlands
  • Eric Serné
    Internal Medicine, Amsterdam UMC location VUmc, Netherlands
  • Mike Nurmohamed
    Rheumatology, Amsterdam UMC location VUmc, Netherlands
  • Irene van der Horst- Bruinsma
    Rheumatology, Amsterdam UMC location VUmc, Netherlands
  • Frank D Verbraak
    Opthalmology, Amsterdam UMC location VUmc, Almere, Netherlands
  • Footnotes
    Commercial Relationships   Buket Kinaci- Tas, None; Rianne van Bentum, None; Milad Baniaamam, None; Aleid van de Kreeke, None; Merve Koçyiğit, None; Eric Serné, None; Mike Nurmohamed, None; Irene van der Horst- Bruinsma, None; Frank Verbraak, None
  • Footnotes
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Investigative Ophthalmology & Visual Science July 2019, Vol.60, 2588. doi:https://doi.org/
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      Buket Kinaci- Tas, Rianne van Bentum, Milad Baniaamam, Aleid van de Kreeke, Merve Koçyiğit, Eric Serné, Mike Nurmohamed, Irene van der Horst- Bruinsma, Frank D Verbraak; Association between retinal vessel analysis and cardiovascular risk profile in Ankylosing Spondylitis patients. Interim analysis of the -An eye for a heart- study.. Invest. Ophthalmol. Vis. Sci. 2019;60(9):2588. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Chronic systemic inflammation in patients with ankylosing spondylitis (AS) contributes to the development of endothelial dysfunction inducing the formation of atherosclerosis, which is associated with cardiovascular diseases (CVD). Retinal vascular visualization could provide information of structural changes of the microcirculation, thereby predict CVD. We conducted a cross sectional study to assess the possible association between retinal vessels and the cardiovascular risk profile in patients with AS.

Methods : In October 2018, an (ongoing) cross sectional study was started including patients aged between 50 and 75 years old with a diagnosis of ankylosing spondylitis according to the modified New York criteria, who consecutively attended the Rheumatology outpatient clinic of the VU medical center and the Jan van Breemen institute (Reade). Patients with diabetes mellitus and known cerebrovascular diseases were excluded. Sociodemographic data, disease activity and the cardiovascular risk profile were assessed. Patients were divided into two groups, with and without known cardiovascular risk factors. We measured 5 retinal retinal vascular parameters identified by the Singapore Vessel Assessment (SIVA) software; central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), the retinal arteriovenous ratio (AVR), curvature tortuosity arterioles (cTORTa), and curvature tortuosity venules (cTORTv). Groups were compared regarding to the vascular parameters with the Mann Whitney U test.

Results : Twenty-seven patients, twenty with and seven without known cardiovascular risk factors, were included (median age 60, IQR 55-66, mean disease duration 23±10 years) were included. Vascular parameters did not significantly differ between patients with and without cardiovascular risk factors. Also no correlation has been found between retinal vascular parameters and disease activity.

Conclusions : In this preliminary analysis no relation was found between the retinal vascular parameters and cardiovascular risk profile in a group of patients with AS.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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