Abstract
Purpose :
To evaluate the seroprevalence of toxocara spp. in patients with uveitis and central serous chorioretinopathy(CSCR) and compare the clinical manifestations of between seropositive and seronegative patients with CSCR.
Methods :
We retrospectively reviewed medical records of 117 patients with uveitis and 94 patients with CSC referred to our hospital from 2012 to 2018. We compared the seroprevalence of toxocara spp. between uveitis and CSC patients. The Visual acuity, clinical presentations and features in clinical images were compared between the toxocara seropositive and negative groups of CSCR at baseline and last visit.
Results :
The seroprevalence rate was 26.5%(31/117) for uveitis and 43.6%(41/94) for CSC, which was significantly higher in CSCR(p = 0.009) patients. In patients with CSCR the mean age(P = 0.006), male ratio(P = 0.026) and disease recurrence rate (P = 0.044) were significantly higher in seropositive group. The final visual acuity was lower in seropositive group than negative group(p=0.045). Optical coherence tomography(OCT) analysis showed that intraretinal fluid, pigment epithelial detachment, subretinal fibrin, RPE irregularity, outer retinal thickening and subfoveal choroidal thickness were higher in seropositive group at presentation. Angiographic analysis showed that diffuse leakage and choroidal vessel dilatation were common in seropositive group.
Conclusions :
CSCR patients with toxocara seropositivity showed diffuse RPE damage in OCT and multiple leakage and more severe choroidal vascular dilatation in angiography compared to seronegative patients. The difference in these findings was related to the recurrence rate and visual prognosis of CSCR.
This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.