July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Epidemiology, laboratory and image profile of Sjögren’s syndrome
Author Affiliations & Notes
  • Eduardo M Rocha
    Ophthalmology, FMRP-USP, Ribeirao Preto, S�o Paulo, Brazil
  • Carolina Maria Modulo
    Ophthalmology, FMRP-USP, Ribeirao Preto, S�o Paulo, Brazil
  • Ana Carolina Fragoso Motta
    FORP-USP, Ribeirao Preto, SP, Brazil
  • Amanda Pires Barbosa
    Ophthalmology, FMRP-USP, Ribeirao Preto, S�o Paulo, Brazil
  • Anna Flora Teixeira Soto Pelinson
    Ophthalmology, FMRP-USP, Ribeirao Preto, S�o Paulo, Brazil
  • Alfredo Ribeiro-Silva
    Pathology, FMRP-USP, Ribeirao Preto, SP, Brazil
  • Denny Marcos Garcia
    Ophthalmology, FMRP-USP, Ribeirao Preto, S�o Paulo, Brazil
  • Valdair Francisco Muglia
    Clinical Medicine, FMRP-USP, Ribeirão Preto, SP, Brazil
  • Paulo Louzada Junior
    Clinical Medicine, FMRP-USP, Ribeirão Preto, SP, Brazil
  • Fabíola Reis Oliveira
    Clinical Medicine, FMRP-USP, Ribeirão Preto, SP, Brazil
  • Footnotes
    Commercial Relationships   Eduardo Rocha, None; Carolina Modulo, None; Ana Fragoso Motta, None; Amanda Barbosa, None; Anna Pelinson, None; Alfredo Ribeiro-Silva, None; Denny Garcia, None; Valdair Muglia, None; Paulo Louzada Junior, None; Fabíola Reis Oliveira, None
  • Footnotes
    Support  The authors would like to acknowledge the following Brazilian public agencies for financial support: Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) (2014-23211-0), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (32355-2017-0), Coordenação de Pessoal de Nível Superior (CAPES) (Finance code 001) e Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (FAEPA)
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 2749. doi:https://doi.org/
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    • Get Citation

      Eduardo M Rocha, Carolina Maria Modulo, Ana Carolina Fragoso Motta, Amanda Pires Barbosa, Anna Flora Teixeira Soto Pelinson, Alfredo Ribeiro-Silva, Denny Marcos Garcia, Valdair Francisco Muglia, Paulo Louzada Junior, Fabíola Reis Oliveira; Epidemiology, laboratory and image profile of Sjögren’s syndrome. Invest. Ophthalmol. Vis. Sci. 2019;60(9):2749. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Sjögren syndrome (SS) is present worldwide, with unknown cause and cure. The present work describes a large series of SS patients observed in Brazil and compare the data among SS and non-SS (NSS) patients, investigated for causes of dry eye and dry mouth.

Methods : A spontaneous sample of individuals with dry eye and/or dry mouth, referred from January 2012 to November 2018, were evaluated and classified as Primary SS (SS1), Secondary SS (SS2) or NSS, based on the American European Consensus. The demographic, clinical and laboratory aspects were analyzed. Images were analyzed for volume, the signal intensity ratio of Lacrimal gland (LG) and vitreous (LG/V), the signal intensity ratio of the ipsilateral parotid gland to vitreous (PG/V) and apparent diffusion coefficient (ADC) of LG and PG (DWI sequence with b=1000 mm/s2), and trigeminal ganglion (TG) volume using the 3.0 Tesla Magnetic Resonance Scanner.

Results : From a total of 418 individuals, 323 (77.3%) completed the exams and were classified as SS or NSS (255 and 68, respectively, where 153 were SS1 and 102 were SS2). The estimated prevalence of SS in the region is one case per 10,000 inhabitants. The mean age is 52.8 ± 15.7 years old, and 93% are women. The sex ratio distribution and the frequency of dry eye symptoms (DES) and dry mouth symptoms (DMS) were similar among the groups (P>0.05). There were no differences in OSDI score, Schirmer’s test (ST), salivary flow or corneal fluorescein staining measures among the groups (P>0.05). Rheumatoid factor (RF) and Antinuclear antibody (ANA), SSa, SSb, gamma fraction, beta-2 microglobulin and lip biopsy focus score were more frequently altered in SS1 and SS2 compared to NSS patients (P<0.05). The TG volume was significantly smaller in the SS group (P=0.0003).

Conclusions : Our data indicate that SS is frequent and that clinical signs and symptoms are not sufficient to distinguish SS from other causes of dry eye and dry mouth. Laboratory exams and MRI are useful to early diagnosis of SS, allowing specific treatment and prevent further complications.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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