July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Clinical and histopathologic ophthalmic findings in a population of rhesus macaques (Macaca mulatta) with a remote history of high dose gamma radiation exposure.
Author Affiliations & Notes
  • William Carrera
    Ophthalmology, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, United States
    Ophthalmology, California Pacific Medical Center, Encinitas, California, United States
  • Greg Dugan
    Pathology, Section on Comparative Medicine, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, United States
  • Robert Carrera
    Columbia University Vagelos College of Physicians and Surgeons, New York, New York, United States
  • J. Mark Cline
    Pathology, Section on Comparative Medicine, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, United States
  • Jessica Weinstein
    Ophthalmology, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, United States
  • Margaret Greven
    Ophthalmology, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, United States
  • Footnotes
    Commercial Relationships   William Carrera, None; Greg Dugan, None; Robert Carrera, None; J. Mark Cline, None; Jessica Weinstein, None; Margaret Greven, None
  • Footnotes
    Support  NIH grant U19 AI67798
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 2972. doi:
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      William Carrera, Greg Dugan, Robert Carrera, J. Mark Cline, Jessica Weinstein, Margaret Greven; Clinical and histopathologic ophthalmic findings in a population of rhesus macaques (Macaca mulatta) with a remote history of high dose gamma radiation exposure.. Invest. Ophthalmol. Vis. Sci. 2019;60(9):2972.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The Rhesus macaque (Macaca mulatta) is of interest as a potential animal model for a variety of diseases, including age-related macular degeneration (AMD), radiation retinopathy (RR) and cataractogenesis. However, these potential models are incompletely characterized and, in some cases, there is no agreed upon method for describing pathologic findings.

Methods : We performed fundus examinations and photography on 83 Rhesus macaques randomly selected from a cohort of long term survivors of high-dose, single fraction gamma irradiation, as well as age and sex-matched controls. 31 eyes from 17 animals from the same cohort who had died prior to the current study were examined histologically.

Results : Macular drusen were observed funduscopically in 56% of animals and histologically in 25.8%. Disciform scarring was noted in one animal. Histologic evidence of RR was noted in one eye. Cataract prevalence was 57.8%, of which posterior subcapsular cataracts (PSC) were most frequent (36.1%). PSC prevalence was associated with prior radiation exposure, although drusen prevalence and severity were not. Drusen severity was associated with age, and this association was found to be influenced by female gender.

Conclusions : We propose an adjunctive scheme for description of advanced drusen in Rhesus macaques based on fundoscopic appearance and drusen distribution pattern. Rhesus macaques manifest ophthalmic findings of a variety of diseases of interest and remain an interesting potential animal model; our study highlights several challenges and topics that would benefit from further longitudinal studies.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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