July 2019
Volume 60, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2019
Early local activation of complement in aqueous humor of patients with age-related macular degeneration
Author Affiliations & Notes
  • Lebriz Altay
    University of Cologne, Department of Ophthalmology, Cologne, Germany
  • Tina Schick
    University of Cologne, Department of Ophthalmology, Cologne, Germany
  • Gabriella Widmer
    Roche Pharma Research and Early Development, Roche Innovation Center Basel, Switzerland
  • Guillemette Duchateau-Nguyen
    Roche Pharma Research and Early Development, Roche Innovation Center Basel, Switzerland
  • Paulo Piraino
    P Value Research S.R.L., Italy
  • Ashwath Jayagopal
    Roche Pharma Research and Early Development, Roche Innovation Center Basel, Switzerland
  • Faye Drawnel
    Roche Pharma Research and Early Development, Roche Innovation Center Basel, Switzerland
  • Sascha Fauser
    University of Cologne, Department of Ophthalmology, Cologne, Germany
    Roche Pharma Research and Early Development, Roche Innovation Center Basel, Switzerland
  • Footnotes
    Commercial Relationships   Lebriz Altay, None; Tina Schick, None; Gabriella Widmer, Hoffmann La Roche (E); Guillemette Duchateau-Nguyen, Hoffmann La Roche (E); Paulo Piraino, Hoffmann La Roche (C); Ashwath Jayagopal, Hoffmann La Roche (E); Faye Drawnel, Hoffmann La Roche (E); Sascha Fauser, Hoffmann La Roche (E)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2019, Vol.60, 2973. doi:https://doi.org/
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    • Get Citation

      Lebriz Altay, Tina Schick, Gabriella Widmer, Guillemette Duchateau-Nguyen, Paulo Piraino, Ashwath Jayagopal, Faye Drawnel, Sascha Fauser; Early local activation of complement in aqueous humor of patients with age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2019;60(9):2973. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate complement activation in aqueous humor of patients with early, intermediate and neovascular age-related macular degeneration (AMD).

Methods : Aqueous humor of 79 AMD patients (early, intermediate and neovascular) and 77 age-matched controls was prospectively collected. The levels of the complement protein 3 (C3), activation products complement factor 3a (C3a) and Ba, C3b/iC3b, complement factors B, H and I (CFB, CFH and CFI), and total protein concentration were measured. Data were modelled using covariate analysis to assess the impact of age and glaucoma status of patients and total protein concentration of samples on complement protein concentration across groups.

Results : C3a concentration was significantly increased in the aqueous humor of early (p=0.016), intermediate (p=0.003) and neovascular (p=0.018) AMD patients, whilst C3 concentration was significantly increased in early AMD patients only (p=0.019). Levels of CFB and CFH were significantly increased in the aqueous humour of neovascular AMD patients (p=0.023 and p=0.018 respectively).

Conclusions : Our findings provide evidence for early local complement dysregulation in AMD patients, suggesting that complement pathway inhibition may be a clinically-relevant intervention for early stages of AMD.

This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.

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